Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment

NCT03059992 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, open label, non-comparator, single arm study to evaluate the efficacy and safety of ibrexafungerp (SCY-078) in patients ≥ 18 years of age with a documented fungal disease that has been intolerant or refractory (rIFI) to Standard of Care (SoC) antifungal treatment.

Interventions

  • DRUG Ibrexafungerp

Study Locations (20)

New York

  • Memorial Sloan Kettering Cancer Center — New York
  • Weill Cornell Medical College — New York
  • Stony Brook University Medical Center — Stony Brook

California

  • UC Davis Medical Center — Sacramento
  • University of California San Francisco — San Francisco

Georgia

  • Emory University Hospital Midtown — Atlanta
  • Augusta University — Augusta

Michigan

  • University of Michigan — Ann Arbor
  • Wayne State University — Detroit

Minnesota

  • University of Minnesota — Minneapolis
  • Mayo Clinic — Rochester

North Carolina

  • Duke University Medical Center — Durham
  • Wake Forest Baptist Medical Center — Winston-Salem

Texas

  • University of Texas Southwestern Medical Center Dallas — Dallas
  • University of Texas Health Science Center at Houston — Houston

Alabama

  • University of Alabama at Birmingham — Birmingham

Trial Details

FieldValue
Enrollment Target 233 participants
Start Date 2017-04-01
Est. Completion 2023-08-25
Phase Phase 3

Sponsor

Scynexis

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03059992

The ClinicalTrials.gov registry entry for NCT03059992 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 233 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Scynexis, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Invasive Candidiasis appearing as the primary indexed condition, and to 1 intervention — of which Ibrexafungerp is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03059992 reports 20 study locations spanning 12 distinct geographic areas — top geographies include New York, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03059992 about?

NCT03059992 is a clinical study titled "Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment". This is a multicenter, open label, non-comparator, single arm study to evaluate the efficacy and safety of ibrexafungerp (SCY-078) in patients ≥ 18 years of age with a documented fungal disease that has been intolerant or refractory (rIFI) to Standard of Care (SoC) antifungal treatment.

What is the current status of trial NCT03059992?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 233 participants. The study started on 2017-04-01. Estimated completion is 2023-08-25.

What conditions does trial NCT03059992 study?

This clinical trial studies the following conditions: Invasive Candidiasis, Coccidioidomycosis, Histoplasmosis, Invasive Pulmonary Aspergillosis, Mucocutaneous Candidiasis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03059992?

The interventions under investigation include: Ibrexafungerp (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03059992?

This trial is sponsored by Scynexis, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03059992 being conducted?

This trial has 20 study locations across Alabama, California, Georgia, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial