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NCT03030703 · ClinicalTrials.gov registry record · NA
Cystatin SN Binds to Phytic Acid and Predicts Non-heme Iron Bioavailability
A NA study, sponsored by Kansas State University.
- Completed
- Registry status
- NA
- Development phase
- 7
- Enrollment target
NCT03030703 is a NA study that has completed, run by Kansas State University. The registered enrollment target is 7 participants.
The verdict
NCT03030703, a NA study, has completed, sponsored by Kansas State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 7 participants
- Enrollment target
Study Summary
Phytic acid is a known inhibitor of iron bioavailability, although long term studies have suggested possibly exaggerated findings compared to single meal studies, pointing to phytic acid adaptation over time. Salivary proline-rich proteins have been found to reduce tannin-iron chelation, but studies have not explored changes in salivary proteins that may result in phytic acid adaptation. The primary objectives of this study are: 1) To determine whether phytic acid impacts iron bioavailability or status when consumed over time 2) to test whether salivary protein production may impact iron bioavailability with phytic acid supplementation, and 3) to explore in vitro phytic acid salivary binding. Secondary objectives included assessment of the reliability of astringency as a measure of salivary protein production and iron absorption. The study was conducted in an iron absorption study of 7 women, aged 18-35 years old, to determine iron bioavailability with supplementation of 350 mg phytic acid before and after regular, three times daily supplementation for four weeks. Direct iron absorption was measured using area under the curve. Iron status was measured by changes in hemoglobin and ferritin, and was adjusted by participant c-reactive protein levels. Salivary samples were collected before and after supplement consumption during meal challenges, and analyzed on HPLC and by ELISA. Astringency testing was conducted at the end of each meal challenge. In vitro saliva-phytic acid modeling was explored on HPLC, MALDI-TOF, and ELISA. Iron absorption and status markers were analyzed by ANOVA, and mixed-modeling followed by pairwise comparison by least significant differences. Pearson's correlations were used to correlated salivary proteins and astringency with iron bioavailability. The present study will provide important information regarding the approximate influence of phytic acid consumption on iron bioavailability and storage over time in regards to salivary proteins. It
Interventions
- DIETARY_SUPPLEMENT phytic acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2016-11-11 |
| Est. Completion | 2016-12-10 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03030703
The ClinicalTrials.gov registry entry for NCT03030703 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 7 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kansas State University, which has 22 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which phytic acid is the first listed.
NCT03030703 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03030703 about?
NCT03030703 is a clinical study titled "Cystatin SN Binds to Phytic Acid and Predicts Non-heme Iron Bioavailability". Phytic acid is a known inhibitor of iron bioavailability, although long term studies have suggested possibly exaggerated findings compared to single meal studies, pointing to phytic acid adaptation over time. Salivary proline-rich proteins have been found to reduce tannin-iron chelation, but studies...
What is the current status of trial NCT03030703?
This trial is currently completed. It is a NA study. The enrollment target is 7 participants. The study started on 2016-11-11. Estimated completion is 2016-12-10.
What interventions are being tested in trial NCT03030703?
The interventions under investigation include: phytic acid (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03030703?
This trial is sponsored by Kansas State University, which has 22 total clinical trials registered on ClinicalTrials.gov.
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