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NCT03029559 · ClinicalTrials.gov registry record · NA
Intermittent Hypoxia and Inspiratory Threshold Loading to Enhance Inspiratory Muscle Function
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT03029559: Completed NA study, sponsored by University of Florida.
NCT03029559 is a NA study that has completed, run by University of Florida. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03029559, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
Rehabilitation approaches introduce a stimulus to a motor system, with the goal to enhance motor function to patients. For example, exposure to brief and intermittent episodes of mild hypoxia has shown to strengthen synaptic pathways to respiratory and skeletal muscle motor neurons. In humans with spinal cord injury, exposure to intermittent hypoxia (IH) alone or in combination with rehabilitative strategies has shown enhanced motor function. Another strategy known as inspiratory threshold loading, which involves breathing against pressure threshold loads, results in improved inspiratory muscle strength. Although there is evidence supporting the use of IH alone or in combination with other rehabilitative strategies in improving motor function in humans, the impact of exposure to IH or IH with inspiratory threshold loading on inspiratory muscle function and ventilation in humans is unknown.
Primary Outcome
Maximal Inspiratory Pressure(MIP) which is a measure of inspiratory muscle strength will be measured as the MIP recorded at the mouth by a pressure manometer. Subjects will be seated upright in a comfortable chair and the nose occluded with clips. After exhaling to residual volume (RV), subjects place their lips around the mouthpiece and inspire as forcefully as possible for at least three seconds. Repeated measurements will be taken, with a 1- to 2-min rest between trials, until three measureme
Interventions
- OTHER Intermittent Hypoxia
- OTHER Inspiratory Threshold Loading
- OTHER Sham Intermittent Hypoxia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2017-02-17 |
| Est. Completion | 2018-02-19 |
| Phase | NA |
What the finished NCT03029559 record still lists
NCT03029559 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Intermittent Hypoxia is the first listed.
NCT03029559 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03029559 about?
NCT03029559 is a clinical study titled "Intermittent Hypoxia and Inspiratory Threshold Loading to Enhance Inspiratory Muscle Function". Rehabilitation approaches introduce a stimulus to a motor system, with the goal to enhance motor function to patients. For example, exposure to brief and intermittent episodes of mild hypoxia has shown to strengthen synaptic pathways to respiratory and skeletal muscle motor neurons. In humans with s...
What is the current status of trial NCT03029559?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2017-02-17. Estimated completion is 2018-02-19.
What interventions are being tested in trial NCT03029559?
The interventions under investigation include: Intermittent Hypoxia (OTHER), Inspiratory Threshold Loading (OTHER), Sham Intermittent Hypoxia (OTHER).
Who is sponsoring clinical trial NCT03029559?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03029559's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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