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NCT03029546 · ClinicalTrials.gov registry record
Effect of Glucose Load on Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes
A clinical trial, sponsored by Ohio State University.
- Completed
- Registry status
- 105
- Enrollment target
NCT03029546: Completed study, sponsored by Ohio State University.
NCT03029546 is a clinical trial that has completed, run by Ohio State University. The registered enrollment target is 105 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03029546 has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- 105 participants
- Enrollment target
Study Summary
The investigator's main objective is to analyze the effects of a routine prenatal care screening tool (glucola test for gestational diabetes) on maternal inflammation through assessment of maternal circulatory biomarkers and blood pressure. Improving knowledge about routine prenatal care and how a variety of screening factors affect maternal physiology allows the investigators to be educated and informed when caring for mothers with medical co-morbidities. * Determine if an acute glucose load (50g) is associated with an in-vivo and in-vitro increase in the concentration of Advanced Glycation End Products (AGEP's) that, in turn, can impact vascular endothelial reactivity and induce an acute increase in blood pressure. Previous studies generated in the investigators' laboratory showed that circulating soluble Receptor for Advanced Glycation End Products (sRAGE) and Tumor Necrosis Factor (TNF)-a (mediator of acute inflammation) are considered markers of the extent of maternal RAGE activation and/or systemic inflammation, respectively. * Determine how an acute glucose load (50g) at the time of normal screening for gestational diabetes induces an acute increase in the level of sRAGE and TNF-a. If the investigators' hypothesis is confirmed, the investigators will have strong confirmation of the involvement of glycation products and TNF-a in generating the acute negative clinical symptoms of women experiencing a glucose tolerance test, such as headache, nausea, sweating, and bloating.
Primary Outcome
biomarker
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2015-11 |
| Est. Completion | 2019-11 |
What the finished NCT03029546 record still lists
NCT03029546 is an observational study that tracks outcomes without assigning an intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT03029546 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03029546 about?
NCT03029546 is a clinical study titled "Effect of Glucose Load on Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes". The investigator's main objective is to analyze the effects of a routine prenatal care screening tool (glucola test for gestational diabetes) on maternal inflammation through assessment of maternal circulatory biomarkers and blood pressure. Improving knowledge about routine prenatal care and how a v...
What is the current status of trial NCT03029546?
This trial is currently completed. The enrollment target is 105 participants. The study started on 2015-11. Estimated completion is 2019-11.
Who is sponsoring clinical trial NCT03029546?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
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