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NCT03019510 · ClinicalTrials.gov registry record · NA
Lowering Impaired Fasting Glucose Levels With Exercise
A NA study, sponsored by University of Missouri-Columbia.
- Completed
- Registry status
- NA
- Development phase
- 54
- Enrollment target
NCT03019510 is a NA study that has completed, run by University of Missouri-Columbia. The registered enrollment target is 54 participants.
The verdict
NCT03019510, a NA study, has completed, sponsored by University of Missouri-Columbia.
- COMPLETED
- Registry status
- NA
- Development phase
- 54 participants
- Enrollment target
Study Summary
Morning hyperglycemia plays a role in the future development of insulin resistance and type 2 diabetes (T2D) (8) and is associated with numerous microvascular and cardiovascular complications and renal disease. These augmented morning glucose levels are due to an elevated endogenous glucose production (EGP), as a result of a loss of coordination between glucose levels and insulin secretion, and possibly hyperglucagonemia during the overnight period. Exercise stimulates glucose uptake and increases insulin sensitivity acutely, and may be the best lifestyle intervention to minimize the nocturnal rise in glucose levels. Prescription of the timing of exercise relative to a meal and/or to the overnight period may be particularly critical for individuals that have impaired fasting glucose (IFG) levels. Surprisingly little is known about the overnight period when elevated EGP and the synchrony between glucose and c-peptide/glucagon levels becomes disturbed. This novel study will provide insight into the hormonal/metabolic milieu of a dinner meal, the evening and overnight period that occurs in non-obese, OB and OB+IFG individuals; it will also establish if the timing of exercise can attenuate nocturnal glucose elevations, and if this is associated with improved hormonal synchrony. This project will compare EGP, β-cell function and hormonal responses between morning and evening exercise on the postprandial and overnight period in obese individuals with/without IFG levels. Fifty-four subjects will be studied during the evening meal (EGP and β-cell function), postprandially and through the overnight period (1600-0700 h), allowing us to examine some of the potential mechanisms for the elevation in overnight glucose levels. This is the first study that will examine this issue from pre-dinner through the night while previous studies have only examined chronically fasted individuals and this study will lay the groundwork for understanding the pathology of the predawn phenomena in
Interventions
- BEHAVIORAL No exercise
- BEHAVIORAL Morning exercise
- BEHAVIORAL Evening exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2016-10 |
| Est. Completion | 2021-09-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03019510
The ClinicalTrials.gov registry entry for NCT03019510 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 54 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which No exercise is the first listed.
NCT03019510 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03019510 about?
NCT03019510 is a clinical study titled "Lowering Impaired Fasting Glucose Levels With Exercise". Morning hyperglycemia plays a role in the future development of insulin resistance and type 2 diabetes (T2D) (8) and is associated with numerous microvascular and cardiovascular complications and renal disease. These augmented morning glucose levels are due to an elevated endogenous glucose producti...
What is the current status of trial NCT03019510?
This trial is currently completed. It is a NA study. The enrollment target is 54 participants. The study started on 2016-10. Estimated completion is 2021-09-30.
What interventions are being tested in trial NCT03019510?
The interventions under investigation include: No exercise (BEHAVIORAL), Morning exercise (BEHAVIORAL), Evening exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT03019510?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
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