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NCT03016689 · ClinicalTrials.gov registry record
The Sinonasal Cavity as a Reservoir for Upper Airway Bacterial Development
A clinical trial, sponsored by University of Minnesota.
- Completed
- Registry status
- 7
- Enrollment target
NCT03016689: Completed study, sponsored by University of Minnesota.
NCT03016689 is a clinical trial that has completed, run by University of Minnesota. The registered enrollment target is 7 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03016689 has completed, sponsored by University of Minnesota.
- COMPLETED
- Registry status
- 7 participants
- Enrollment target
Study Summary
While the maternal-newborn exchange of airway microbiota is well-documented, no studies have examined within-subject relationships among the mouth, sinuses, nasopharynx and lungs and the relative abundance of bacterial taxa at those sites. Recent evidence suggests the oral cavity may serve as a reservoir for pathogens that translocate to non-oral locations; oral-associated microbes infect most other body sites as evidence by 16S sequencing. By using a combination of oral and throat swabs, together with nasal suction of mucus samples, the investigators will use metagenomic sequencing to characterize the composition of bacterial communities at each anatomical site. Beginning at birth, a time-series of swabs will be collected from each subject, and monitor changes in the development of microbiota over time. By doing so, our studies will illuminate airway trafficking of both beneficial and pathogenic microbes and may represent an essential pathophysiological step towards shifting the balance between airway health and disease.
Primary Outcome
The primary outcome measure will be the development and composition of bacterial communities throughout the respiratory tract during the first year of life. Community composition will be assessed using 16S rRNA sequencing, and differences between body sites will be calculated using standard ecological metrics.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2017-05-31 |
| Est. Completion | 2019-09-12 |
What the finished NCT03016689 record still lists
NCT03016689 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 7 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT03016689 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03016689 about?
NCT03016689 is a clinical study titled "The Sinonasal Cavity as a Reservoir for Upper Airway Bacterial Development". While the maternal-newborn exchange of airway microbiota is well-documented, no studies have examined within-subject relationships among the mouth, sinuses, nasopharynx and lungs and the relative abundance of bacterial taxa at those sites. Recent evidence suggests the oral cavity may serve as a rese...
What is the current status of trial NCT03016689?
This trial is currently completed. The enrollment target is 7 participants. The study started on 2017-05-31. Estimated completion is 2019-09-12.
Who is sponsoring clinical trial NCT03016689?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
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