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Trial of TRC105 and Pazopanib Versus Pazopanib Alone in Patients With Advanced Angiosarcoma
NCT02979899 · View on ClinicalTrials.gov ↗
Study Summary
This is a study of TRC105 in combination with standard dose pazopanib compared to single agent pazopanib in patients with angiosarcoma not amenable to curative intent surgery (e.g., metastatic or bulky disease, and disease for which surgical resection would carry an unacceptable risk to the patient) who have not received pazopanib or TRC105 previously.
Conditions Studied
Interventions
- BIOLOGICAL TRC105
- DRUG Votrient
Study Locations (20)
New York
- Roswell Park Cancer Institute — Buffalo
- Northwell Health — Lake Success
- MSKCC — New York
California
- Stanford University — Palo Alto
- Sarcoma Oncology Center — Santa Monica
Florida
- Mayo Clinic Jacksonville — Jacksonville
- Moffitt Cancer Center — Tampa
Massachusetts
- Massachusetts General Hospital — Boston
- Dana Farber Cancer Institute — Boston
Ohio
- Cleveland Clinic — Cleveland
- Ohio State University — Columbus
Arizona
- University of Arizona Cancer Center — Tucson
Colorado
- University of Colorado Denver — Aurora
Georgia
- Northside Hospital — Sandy Springs
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2017-02-13 |
| Est. Completion | 2019-08-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02979899
The ClinicalTrials.gov registry entry for NCT02979899 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 128 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tracon Pharmaceuticals, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Angiosarcoma appearing as the primary indexed condition, and to 2 interventions — of which TRC105 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02979899 reports 20 study locations spanning 14 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02979899 about?
NCT02979899 is a clinical study titled "Trial of TRC105 and Pazopanib Versus Pazopanib Alone in Patients With Advanced Angiosarcoma". This is a study of TRC105 in combination with standard dose pazopanib compared to single agent pazopanib in patients with angiosarcoma not amenable to curative intent surgery (e.g., metastatic or bulky disease, and disease for which surgical resection would carry an unacceptable risk to the patient)...
What is the current status of trial NCT02979899?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 128 participants. The study started on 2017-02-13. Estimated completion is 2019-08-31.
What conditions does trial NCT02979899 study?
This clinical trial studies the following conditions: Advanced Angiosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02979899?
The interventions under investigation include: TRC105 (BIOLOGICAL), Votrient (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02979899?
This trial is sponsored by Tracon Pharmaceuticals, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02979899 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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