Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer

NCT02947685 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to demonstrate that the combination of palbociclib with anti-HER2 therapy plus endocrine therapy is superior to anti-HER2-based therapy plus endocrine therapy alone in improving the outcomes of subjects with hormone receptor-positive, HER2+ metastatic breast cancer.

Interventions

  • DRUG Anastrozole
  • DRUG letrozole
  • DRUG palbociclib
  • DRUG trastuzumab
  • DRUG pertuzumab

Study Locations (20)

Florida

  • Baycare Healthcare (Morton Plant Mease) — Clearwater
  • Memorial Healthcare System — Hollywood
  • University of Miami — Miami
  • Florida Hospital — Orlando

Illinois

  • University of Illinois at Chicago — Chicago
  • Ingalls Memorial Hospital — Harvey

Maryland

  • University of Maryland - Greenebaum Comprehensive Cancer Center — Baltimore
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore

Massachusetts

  • Dana-Farber Cancer Institute — Boston
  • Lowell General Hospital — Lowell

Michigan

  • Michigan Cancer Research Consortium (St. Joseph Mercy Hospital — Ann Arbor
  • West Michigan Cancer Center — Grand Rapids

Minnesota

  • Metro-Minnesota NCI Community Oncology Research Program — Minneapolis
  • Mayo Clinic, Rochester, MN — Rochester

California

  • UCSF — San Francisco

District of Columbia

  • Georgetown University Medical Center — Washington D.C.

Trial Details

FieldValue
Enrollment Target 518 participants
Start Date 2017-06-21
Est. Completion 2026-07-31
Phase Phase 3

Sponsor

Alliance Foundation Trials

71 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02947685

The ClinicalTrials.gov registry entry for NCT02947685 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 518 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance Foundation Trials, which has 71 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Estrogen Receptor Positive Breast Cancer appearing as the primary indexed condition, and to 5 interventions — of which Anastrozole is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02947685 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Florida, Illinois, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02947685 about?

NCT02947685 is a clinical study titled "Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer". The primary objective of this study is to demonstrate that the combination of palbociclib with anti-HER2 therapy plus endocrine therapy is superior to anti-HER2-based therapy plus endocrine therapy alone in improving the outcomes of subjects with hormone receptor-positive, HER2+ metastatic breast ca...

What is the current status of trial NCT02947685?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 518 participants. The study started on 2017-06-21. Estimated completion is 2026-07-31.

What conditions does trial NCT02947685 study?

This clinical trial studies the following conditions: Estrogen Receptor Positive Breast Cancer, HER-2 Positive Breast Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02947685?

The interventions under investigation include: Anastrozole (DRUG), letrozole (DRUG), palbociclib (DRUG), trastuzumab (DRUG), pertuzumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02947685?

This trial is sponsored by Alliance Foundation Trials, which has 71 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02947685 being conducted?

This trial has 20 study locations across California, District of Columbia, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial