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NCT02945553 · ClinicalTrials.gov registry record · Phase 1
Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
A Phase 1 study, sponsored by University of Vermont.
- Completed
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
NCT02945553: Completed Phase 1 study, sponsored by University of Vermont.
NCT02945553 is a Phase 1 study that has completed, run by University of Vermont. The registered enrollment target is 25 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02945553, a Phase 1 study, has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
Study Summary
Traumatic knee injury is common and highly debilitating. Surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of normal activities, increasing risk of further injury and, in a majority of patients, hastening the development of knee osteoarthritis (OA). Our goal in this research study is to evaluate the utility of neuromuscular electrical stimulation (NMES), initiated following injury and maintained through the early post-surgical period, to prevent muscle atrophy and intrinsic contractile dysfunction compared to active control intervention of micro-electrical stimulation.
Primary Outcome
Cross-sectional area of skeletal muscle fibers will be evaluated using immunohistochemistry, with specification of all relevant muscle fiber types
Interventions
- DEVICE Neuromuscular electrical stimulation
- DEVICE Microstimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2016-10 |
| Est. Completion | 2019-09 |
| Phase | Phase 1 |
What the finished NCT02945553 record still lists
NCT02945553 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 2 interventions - of which Neuromuscular electrical stimulation is the first listed.
NCT02945553 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02945553 about?
NCT02945553 is a clinical study titled "Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery". Traumatic knee injury is common and highly debilitating. Surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of normal activities, increasing risk of further injury and, in a majority of ...
What is the current status of trial NCT02945553?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2016-10. Estimated completion is 2019-09.
What interventions are being tested in trial NCT02945553?
The interventions under investigation include: Neuromuscular electrical stimulation (DEVICE), Microstimulation (DEVICE).
Who is sponsoring clinical trial NCT02945553?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02945553's enrollment target sits among peer trials
25 1495th of 2000 higher than 481 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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