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NCT02944578 · ClinicalTrials.gov registry record · Phase 2
Topical Curcumin for Precancer Cervical Lesions
A Phase 2 study, sponsored by Lisa Flowers.
- Terminated
- Registry status
- Phase 2
- Development phase
- 7
- Enrollment target
NCT02944578: Clinical Trial Phase 2 study, sponsored by Lisa Flowers.
NCT02944578 is a Phase 2 study that was terminated before completion, run by Lisa Flowers. The registered enrollment target is 7 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02944578, a Phase 2 study, was terminated before completion, sponsored by Lisa Flowers.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 7 participants
- Enrollment target
Study Summary
The purpose of this study is to see if curcumin can reverse a cervical precancerous state by looking at people who have the condition and intervening with a study drug or placebo (an inactive drug), prior to planned therapeutic loop electrosurgical excision procedure (LEEP) which is a treatment procedure for removing cervical cancer. 40 women with high grade squamous intraepithelial lesion (HSIL) of the cervix will be enrolled to either insert 2000 mg capsule of curcumin or a placebo in their vagina once a week for 12 weeks. After a 4 week long washout period the participants will then undergo removal of the precancerous cells as recommended standard of care. Participants will have regular monthly visits for the duration of the study.
Primary Outcome
Vaginal samples were used to determine the association between intravaginal curcumin on known HPV-related molecular target HPV E6/E7 mRNA expression within high grade squamous intraepithelial (HSIL) lesions of the cervix in HIV- infected women. The Aptima® HPV Assay that will be utilized detects full-length HPV E6/E7 mRNA for HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 and correlates very well with integrated HPV, which in turn correlates with full-length HPV E6/E7 prote
Interventions
- DRUG Placebo
- DRUG Curcumin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2017-11-20 |
| Est. Completion | 2018-10-30 |
| Phase | Phase 2 |
Why NCT02944578 stopped before completion
NCT02944578 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02944578 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02944578 about?
NCT02944578 is a clinical study titled "Topical Curcumin for Precancer Cervical Lesions". The purpose of this study is to see if curcumin can reverse a cervical precancerous state by looking at people who have the condition and intervening with a study drug or placebo (an inactive drug), prior to planned therapeutic loop electrosurgical excision procedure (LEEP) which is a treatment proc...
What is the current status of trial NCT02944578?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 7 participants. The study started on 2017-11-20. Estimated completion is 2018-10-30.
What interventions are being tested in trial NCT02944578?
The interventions under investigation include: Placebo (DRUG), Curcumin (DRUG).
Who is sponsoring clinical trial NCT02944578?
This trial is sponsored by Lisa Flowers, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02944578's enrollment target sits among peer trials
7 1996th of 2000 higher than 5 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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