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NCT02927392 · ClinicalTrials.gov registry record · NA
Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
A NA study, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 69
- Enrollment target
NCT02927392: Completed NA study, sponsored by University of Colorado, Denver.
NCT02927392 is a NA study that has completed, run by University of Colorado, Denver. The registered enrollment target is 69 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02927392, a NA study, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 69 participants
- Enrollment target
Study Summary
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). The investigators preliminary data suggest that this may be due, in part, to reduced brown adipose tissue (BAT) activity. The overarching hypothesis is that BAT activity in humans is modulated by E2. To determine if natural declines in endogenous E2 contribute to changes in BAT activity, we will compare BAT activity in pre-and post-menopausal women. The investigators will also explore whether suppression of ovarian hormones in pre-menopausal women impairs BAT activity. BAT activity will be quantified using dynamic positron emission topography/computed tomography (PET/CT) imaging combined with 11C-acetate tracers. We will assess the thermogenic response of BAT by measuring cold-induced changes in REE, shivering, and skin and core temperature.
Primary Outcome
Brown adipose tissue volume will be measured using the radioactive tracer 18Fluro-deoxyglucose.
Interventions
- DRUG Leuprolide acetate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2017-03-16 |
| Est. Completion | 2023-05-02 |
| Phase | NA |
What the finished NCT02927392 record still lists
NCT02927392 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 69 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which Leuprolide acetate is the first listed.
NCT02927392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02927392 about?
NCT02927392 is a clinical study titled "Brown Adipose Tissue Activity in Pre- and Postmenopausal Women". The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). The investigators preliminary d...
What is the current status of trial NCT02927392?
This trial is currently completed. It is a NA study. The enrollment target is 69 participants. The study started on 2017-03-16. Estimated completion is 2023-05-02.
What interventions are being tested in trial NCT02927392?
The interventions under investigation include: Leuprolide acetate (DRUG).
Who is sponsoring clinical trial NCT02927392?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02927392's enrollment target sits among peer trials
69 1133rd of 2000 higher than 868 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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