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NCT02927392 · ClinicalTrials.gov registry record · NA
Brown Adipose Tissue Activity in Pre- and Postmenopausal Women
A NA study, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 69
- Enrollment target
NCT02927392 is a NA study that has completed, run by University of Colorado, Denver. The registered enrollment target is 69 participants.
The verdict
NCT02927392, a NA study, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 69 participants
- Enrollment target
Study Summary
The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). The investigators preliminary data suggest that this may be due, in part, to reduced brown adipose tissue (BAT) activity. The overarching hypothesis is that BAT activity in humans is modulated by E2. To determine if natural declines in endogenous E2 contribute to changes in BAT activity, we will compare BAT activity in pre-and post-menopausal women. The investigators will also explore whether suppression of ovarian hormones in pre-menopausal women impairs BAT activity. BAT activity will be quantified using dynamic positron emission topography/computed tomography (PET/CT) imaging combined with 11C-acetate tracers. We will assess the thermogenic response of BAT by measuring cold-induced changes in REE, shivering, and skin and core temperature.
Interventions
- DRUG Leuprolide acetate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2017-03-16 |
| Est. Completion | 2023-05-02 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02927392
The ClinicalTrials.gov registry entry for NCT02927392 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 69 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Leuprolide acetate is the first listed.
NCT02927392 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02927392 about?
NCT02927392 is a clinical study titled "Brown Adipose Tissue Activity in Pre- and Postmenopausal Women". The physiological relevance of brown adipose tissue (BAT) in humans is largely unknown. The investigators have shown that suppressing ovarian function in premenopausal women reduces resting energy expenditure (REE), and this is prevented by adding back estradiol (E2). The investigators preliminary d...
What is the current status of trial NCT02927392?
This trial is currently completed. It is a NA study. The enrollment target is 69 participants. The study started on 2017-03-16. Estimated completion is 2023-05-02.
What interventions are being tested in trial NCT02927392?
The interventions under investigation include: Leuprolide acetate (DRUG).
Who is sponsoring clinical trial NCT02927392?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
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