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NCT02897843 · ClinicalTrials.gov registry record · NA
The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy
A NA study, sponsored by Northwell Health.
- Completed
- Registry status
- NA
- Development phase
- 32
- Enrollment target
NCT02897843 is a NA study that has completed, run by Northwell Health. The registered enrollment target is 32 participants.
The verdict
NCT02897843, a NA study, has completed, sponsored by Northwell Health.
- COMPLETED
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
Study Summary
Electroconvulsive therapy (ECT) is an effective treatment for a variety of psychiatric disorders. However, despite continued advances in ECT technique, neurocognitive dysfunction continues to be a frequent adverse effect. Declarative memory and less so selective memory are often impaired after an ECT course. Immediate memory, however, is broadly preserved. It is hypothesized that memory impairments are due to ECT induced disruptions on long term potentiation as well as in cerebral flux and glutamatergic and cholinergic systems. Different pharmacological agents for the treatment of ECT induced cognitive dysfunction have been tried. Agents such as opioids, vasopressin, neuropeptides, cholinergic agents, thyroid hormone, and stimulants have been used with equivocal results, and no controlled studies showed clear efficacy. Transcranial direct current stimulation (tDCS) is a non-invasive, painless brain stimulation treatment that uses direct electrical currents to stimulate specific parts of the brain. Electrical currents are applied constantly at low intensities (1-2 mA) over a long period, usually in minutes (5-30 minutes), to achieve changes in cortical excitability by influencing spontaneous neural activity. There are two types of stimulation with tDCS: anodal and cathodal stimulation. Anodal stimulation acts to excite neuronal activity while cathodal stimulation inhibits or reduces neuronal activity. Several studies demonstrated moderate to strong effect sizes of tDCS in various neurocognitive and neuropsychiatric settings. Majority of studies show positive effects of tDCS on cognitive functioning among healthy volunteers and subjects with neurological or psychiatric conditions. Beneficial effects of online stimulation applied over the left dorsolateral prefrontal cortex have been reported for working memory, attention and information processing in depressed patients. To the investigators' knowledge no studies have evaluated the potential efficacy of tDCS for the p
Interventions
- DEVICE sham tDCS
- DEVICE transcranial magnetic stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2017-02-16 |
| Est. Completion | 2019-04-19 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02897843
The ClinicalTrials.gov registry entry for NCT02897843 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwell Health, which has 370 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which sham tDCS is the first listed.
NCT02897843 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02897843 about?
NCT02897843 is a clinical study titled "The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy". Electroconvulsive therapy (ECT) is an effective treatment for a variety of psychiatric disorders. However, despite continued advances in ECT technique, neurocognitive dysfunction continues to be a frequent adverse effect. Declarative memory and less so selective memory are often impaired after an EC...
What is the current status of trial NCT02897843?
This trial is currently completed. It is a NA study. The enrollment target is 32 participants. The study started on 2017-02-16. Estimated completion is 2019-04-19.
What interventions are being tested in trial NCT02897843?
The interventions under investigation include: sham tDCS (DEVICE), transcranial magnetic stimulation (DEVICE).
Who is sponsoring clinical trial NCT02897843?
This trial is sponsored by Northwell Health, which has 370 total clinical trials registered on ClinicalTrials.gov.
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