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NCT02848729 · ClinicalTrials.gov registry record · Phase 4
Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
A Phase 4 study, sponsored by Mallinckrodt.
- Completed
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
NCT02848729 is a Phase 4 study that has completed, run by Mallinckrodt. The registered enrollment target is 50 participants.
The verdict
NCT02848729, a Phase 4 study, has completed, sponsored by Mallinckrodt.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
Study Summary
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills. It can even change what the body does to the drug \[pharmacokinetics (PK)\]. Some doctors have started using intravenous (IV) APAP with morphine, instead of the pills. This study will measure the PK of APAP pills and IV when used with morphine in healthy volunteers. IV APAP will likely be more effective and cause fewer side effects when used with morphine to treat pain after surgery.
Interventions
- DRUG Saline
- DRUG Placebo Tablets
- DRUG IV Acetaminophen
- DRUG Oral Acetaminophen
- DRUG IV Morphine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2016-02 |
| Est. Completion | 2016-03 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02848729
The ClinicalTrials.gov registry entry for NCT02848729 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mallinckrodt, which has 69 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Saline is the first listed.
NCT02848729 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02848729 about?
NCT02848729 is a clinical study titled "Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen". Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills. It can even change what the body does to the drug \[pharmacokinetics ...
What is the current status of trial NCT02848729?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2016-02. Estimated completion is 2016-03.
What interventions are being tested in trial NCT02848729?
The interventions under investigation include: Saline (DRUG), Placebo Tablets (DRUG), IV Acetaminophen (DRUG), Oral Acetaminophen (DRUG), IV Morphine (DRUG).
Who is sponsoring clinical trial NCT02848729?
This trial is sponsored by Mallinckrodt, which has 69 total clinical trials registered on ClinicalTrials.gov.
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