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NCT02836899 · ClinicalTrials.gov registry record · Phase 3
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
A Phase 3 study, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Phase 3
- Development phase
- 250
- Enrollment target
NCT02836899: Completed Phase 3 study, sponsored by Massachusetts General Hospital.
NCT02836899 is a Phase 3 study that has completed, run by Massachusetts General Hospital. The registered enrollment target is 250 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02836899, a Phase 3 study, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 250 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing prolonged cardiopulmonary bypass.
Primary Outcome
Acute kidney injury (AKI) is defined by KDIGO criteria as an abrupt (within 48h) reduction in kidney function correlated to an absolute increase in serum creatinine of 0.3 mg/dL or more (≥26.4 μmol/L) or a percentage increase in serum creatinine of 50% or more (1.5-fold from baseline) at any time during the first 7 days after surgery or, finally, a reduction in urine output with a documented oliguria of \< 0.5 ml/Kg/h for \>6h.
Interventions
- OTHER Placebo
- DRUG Nitric Oxide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2017-02-08 |
| Est. Completion | 2025-08-15 |
| Phase | Phase 3 |
What the finished NCT02836899 record still lists
NCT02836899 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02836899 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02836899 about?
NCT02836899 is a clinical study titled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.". The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing prolonged cardiopulmonary bypass.
What is the current status of trial NCT02836899?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 250 participants. The study started on 2017-02-08. Estimated completion is 2025-08-15.
What interventions are being tested in trial NCT02836899?
The interventions under investigation include: Placebo (OTHER), Nitric Oxide (DRUG).
Who is sponsoring clinical trial NCT02836899?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02836899's enrollment target sits among peer trials
250 1249th of 2000 higher than 735 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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