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NCT02772783 · ClinicalTrials.gov registry record · NA
Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus
A NA study, sponsored by Boston Children's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT02772783: Completed NA study, sponsored by Boston Children's Hospital.
NCT02772783 is a NA study that has completed, run by Boston Children's Hospital. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02772783, a NA study, has completed, sponsored by Boston Children's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
Processed carbohydrates cause rapid changes in blood sugar and have been associated with overeating and obesity. We have shown that test meals high in processed carbohydrate affect brain areas involved in addiction, craving and overeating. It is unknown whether the changes in blood sugar or the associated higher insulin levels mediate this brain activation and its likely adverse effects. Answering this question is important for patients with type 1 diabetes who have elevated risks of obesity and disordered eating: If blood sugar is the causal mechanism, optimal insulin coverage should be protective. If insulin is the causal mechanism, however, a diet high in processed carbohydrate could predispose to overeating and weight gain, as this diet requires higher insulin doses. To disentangle these factors, we will study brain activation and relevant blood markers in 15 men with diabetes. In 4 sessions, we will examine meals with differential carbohydrate properties while giving insulin infusions.
Primary Outcome
Cerebral blood flow in the right and left nucleus accumbent was measured by arterial spin labeling (MRI). Blood flow was normalized for whole brain perfusion and corrected for baseline perfusion in the respective brain area and meal order, as per our a priori statistical analysis plan.
Interventions
- OTHER high GI meal
- OTHER low GI meal
- DRUG euglycemic insulin clamp
- DRUG primed-variable insulin infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2016-07 |
| Est. Completion | 2018-05 |
| Phase | NA |
What the finished NCT02772783 record still lists
NCT02772783 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 4 interventions - of which high GI meal is the first listed.
NCT02772783 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02772783 about?
NCT02772783 is a clinical study titled "Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus". Processed carbohydrates cause rapid changes in blood sugar and have been associated with overeating and obesity. We have shown that test meals high in processed carbohydrate affect brain areas involved in addiction, craving and overeating. It is unknown whether the changes in blood sugar or the asso...
What is the current status of trial NCT02772783?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2016-07. Estimated completion is 2018-05.
What interventions are being tested in trial NCT02772783?
The interventions under investigation include: high GI meal (OTHER), low GI meal (OTHER), euglycemic insulin clamp (DRUG), primed-variable insulin infusion (DRUG).
Who is sponsoring clinical trial NCT02772783?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02772783's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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