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NCT02768688 · ClinicalTrials.gov registry record · Early Phase 1
MRI of Glymphatic Clearance During Anesthetic Sedation
A Early Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 17
- Enrollment target
NCT02768688: Completed Early Phase 1 study, sponsored by University of Pennsylvania.
NCT02768688 is a Early Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 17 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02768688, a Early Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 17 participants
- Enrollment target
Study Summary
This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI. The study is designed to measure clinically established, safe imaging of DTI and cerebral blood flow at baseline, during a continuous intravenous infusion of dexmedetomidine at doses designed to produce anesthesia-induced unconsciousness to simulate natural sleep, and again on return to wakefulness.
Primary Outcome
Assessment of the effect of dexmedetomidine anesthesia on glymphatic flow in subjects as visualized by diffusion tensor MRI.
Interventions
- DRUG Dexmedetomidine
- OTHER Brain connectivity and physiology
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2014-07 |
| Est. Completion | 2017-12 |
| Phase | Early Phase 1 |
What the finished NCT02768688 record still lists
NCT02768688 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 2 interventions - of which Dexmedetomidine is the first listed.
NCT02768688 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02768688 about?
NCT02768688 is a clinical study titled "MRI of Glymphatic Clearance During Anesthetic Sedation". This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI. The study is designed to measure clinically established, safe imaging of DTI and cerebral blood flow at baseline, during a continuous intravenous inf...
What is the current status of trial NCT02768688?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 17 participants. The study started on 2014-07. Estimated completion is 2017-12.
What interventions are being tested in trial NCT02768688?
The interventions under investigation include: Dexmedetomidine (DRUG), Brain connectivity and physiology (OTHER).
Who is sponsoring clinical trial NCT02768688?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02768688's enrollment target sits among peer trials
17 1351st of 2000 higher than 632 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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