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NCT02767388 · ClinicalTrials.gov registry record
Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery
A clinical trial, sponsored by University of Nebraska.
- Completed
- Registry status
- 45
- Enrollment target
NCT02767388 is a clinical trial that has completed, run by University of Nebraska. The registered enrollment target is 45 participants.
The verdict
NCT02767388 has completed, sponsored by University of Nebraska.
- COMPLETED
- Registry status
- 45 participants
- Enrollment target
Study Summary
Broadly speaking, the goal of this study is to better understand the influence of chemotherapy treatment on the cognitive and neural mechanisms underlying human behavior. Extant literature lacks diversity in studied cancer populations and treatment protocols, and provides limited understanding of the cognitive abilities that are impaired by chemotherapy. To overcome these limitations, this study will employ a sophisticated battery of tests on an understudied cancer population. Eligible participants will either be patients diagnosed with hematological malignancy (HM) or demographically matched healthy control patients. After HM diagnosis and treatment protocols have been established, patients will be inducted into the longitudinal study comprised of three visits: 1) after diagnosis but prior to chemotherapy treatment (baseline), 2) after one treatment cycle (one month post-baseline), and 3) after three treatment cycles (three months post-baseline). Patients will undergo a test battery designed to measure specific behavioral and neural mechanisms of attention; tests will either be computer-based cognitive tasks or simulated driving tests that immerse patients into virtual driving scenarios. During each test, EEG will be concurrently measured through non-invasive scalp electrophysiology recordings; EEG recordings will reveal underlying neural mechanisms affected by chemotherapy. Additionally, neuropsychological tests of vision, attention, and memory will be administered, as well as questionnaires to evaluate health, mobility, and life space. Finally, blood samples will be collected to examine levels of circulating inflammation-specific proteins typically present in cancer patients. This study will allow us to better understand the mechanisms through which chemotherapy influences cognitive performance. Results from this study will influence the administration of chemotherapy treatments so that patients can continue to receive the highest medical care while maintaining
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2016-09-01 |
| Est. Completion | 2018-03-15 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02767388
The ClinicalTrials.gov registry entry for NCT02767388 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Nebraska, which has 407 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT02767388 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02767388 about?
NCT02767388 is a clinical study titled "Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery". Broadly speaking, the goal of this study is to better understand the influence of chemotherapy treatment on the cognitive and neural mechanisms underlying human behavior. Extant literature lacks diversity in studied cancer populations and treatment protocols, and provides limited understanding of th...
What is the current status of trial NCT02767388?
This trial is currently completed. The enrollment target is 45 participants. The study started on 2016-09-01. Estimated completion is 2018-03-15.
Who is sponsoring clinical trial NCT02767388?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
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