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COMPLETED Phase 3

A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy

NCT02755597 · View on ClinicalTrials.gov ↗

Study Summary

This was a Phase 3, multicenter, randomized, double blind, placebo-controlled study evaluating the efficacy and safety of venetoclax plus bortezomib and dexamethasone in participants with relapsed or refractory multiple myeloma who are considered sensitive or naïve to proteasome inhibitors and received 1 to 3 prior lines of therapy for multiple myeloma.

Interventions

  • DRUG Venetoclax
  • DRUG Dexamethasone
  • DRUG Bortezomib
  • DRUG Placebo for venetoclax

Study Locations (20)

New South Wales

  • Royal Prince Alfred Hospital /ID# 149108 — Camperdown
  • Concord Repatriation General Hospital /ID# 149106 — Concord
  • Liverpool Hospital /ID# 149110 — Liverpool

Victoria

  • Box Hill Hospital /ID# 149112 — Box Hill
  • Peter MacCallum Cancer Ctr /ID# 149107 — Melbourne
  • Alfred Health /ID# 150085 — Melbourne

Colorado

  • Rocky Mountain Regional VA Medical Center/Eastern Colorado Health Care System /ID# 156524 — Aurora
  • Univ of Colorado Cancer Center /ID# 149130 — Aurora

Western Australia

  • Fiona Stanley Hospital /ID# 148967 — Murdoch
  • Perth Blood Institute Ltd /ID# 148966 — Nedlands

North Carolina

  • Duke Cancer Center /ID# 149099 — Durham

Ohio

  • Gabrail Cancer Center Research /ID# 149098 — Canton

Queensland

  • Royal Brisbane and Women's Hospital /ID# 149105 — Herston

South Australia

  • The Queen Elizabeth Hospital /ID# 149104 — Woodville South

Trial Details

FieldValue
Enrollment Target 291 participants
Start Date 2016-07-11
Est. Completion 2022-08-15
Phase Phase 3

Sponsor

AbbVie

603 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02755597

The ClinicalTrials.gov registry entry for NCT02755597 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 291 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed/Refractory Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Venetoclax is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02755597 reports 20 study locations spanning 14 distinct geographic areas — top geographies include New South Wales, Victoria, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02755597 about?

NCT02755597 is a clinical study titled "A Study Evaluating Venetoclax (ABT-199) in Multiple Myeloma Subjects Who Are Receiving Bortezomib and Dexamethasone as Standard Therapy". This was a Phase 3, multicenter, randomized, double blind, placebo-controlled study evaluating the efficacy and safety of venetoclax plus bortezomib and dexamethasone in participants with relapsed or refractory multiple myeloma who are considered sensitive or naïve to proteasome inhibitors and recei...

What is the current status of trial NCT02755597?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 291 participants. The study started on 2016-07-11. Estimated completion is 2022-08-15.

What conditions does trial NCT02755597 study?

This clinical trial studies the following conditions: Relapsed/Refractory Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02755597?

The interventions under investigation include: Venetoclax (DRUG), Dexamethasone (DRUG), Bortezomib (DRUG), Placebo for venetoclax (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02755597?

This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02755597 being conducted?

This trial has 20 study locations across Colorado, North Carolina, Ohio, New South Wales, Queensland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial