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NCT02744287 · ClinicalTrials.gov registry record · Phase 1
Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors
A Phase 1 study, sponsored by Regeneron Pharmaceuticals.
- Terminated
- Registry status
- Phase 1
- Development phase
- 52
- Enrollment target
NCT02744287: Clinical Trial Phase 1 study, sponsored by Regeneron Pharmaceuticals.
NCT02744287 is a Phase 1 study that was terminated before completion, run by Regeneron Pharmaceuticals. The registered enrollment target is 52 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02744287, a Phase 1 study, was terminated before completion, sponsored by Regeneron Pharmaceuticals.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 52 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety and activity of BPX-601 CAR-T cells in participants with previously treated advanced solid tumors (prostate) expressing high levels of prostate stem cell antigen (PSCA). Participants' T cells are modified to recognize and target the PSCA tumor marker on cancer cells.
Primary Outcome
Incidence of dose limiting toxicity
Interventions
- DRUG Rimiducid
- BIOLOGICAL BPX-601
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2016-11-30 |
| Est. Completion | 2023-03-14 |
| Phase | Phase 1 |
Why NCT02744287 stopped before completion
NCT02744287 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower).
The record links to 0 conditions, and to 2 interventions - of which Rimiducid is the first listed.
NCT02744287 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02744287 about?
NCT02744287 is a clinical study titled "Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors". The purpose of this study is to evaluate the safety and activity of BPX-601 CAR-T cells in participants with previously treated advanced solid tumors (prostate) expressing high levels of prostate stem cell antigen (PSCA). Participants' T cells are modified to recognize and target the PSCA tumor mark...
What is the current status of trial NCT02744287?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2016-11-30. Estimated completion is 2023-03-14.
What interventions are being tested in trial NCT02744287?
The interventions under investigation include: Rimiducid (DRUG), BPX-601 (BIOLOGICAL).
Who is sponsoring clinical trial NCT02744287?
This trial is sponsored by Regeneron Pharmaceuticals, which has 280 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02744287's enrollment target sits among peer trials
52 956th of 2000 higher than 1,032 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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