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NCT02734368 · ClinicalTrials.gov registry record
A Prospective, Cohort Study of Hyperpolarized 3He MRI in Chronic Obstructive Pulmonary Disease
A clinical trial, sponsored by University of Pennsylvania.
- Terminated
- Registry status
- 53
- Enrollment target
NCT02734368: Clinical Trial study, sponsored by University of Pennsylvania.
NCT02734368 is a clinical trial that was terminated before completion, run by University of Pennsylvania. The registered enrollment target is 53 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02734368 was terminated before completion, sponsored by University of Pennsylvania.
- TERMINATED
- Registry status
- 53 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the MRI characteristics of Chronic Obstructive Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function tests, CT scan, 6 Minute-walk tests, and respiratory questionnaires. The central hypothesis is that quantitative assessment of the lung through magnetic resonance imaging of hyperpolarized 3He can detect early alterations in structure and function which are precursors to clinically apparent COPD and that these precursors can be used to predict progression of disease earlier and better than established clinical methods. Novel assessments using 3He MRI will lead to new information about COPD and will be critical for characterizing disease response to therapy. A secondary hypothesis is that a variety of technical improvements in the techniques of hyperpolarized gas MRI will accelerate the translation of this relatively new modality to clinical use.
Primary Outcome
To measure the specificity and sensitivity of Regional Alveolar Oxygen Tension Heterogeneity in differentiation of healthy smokers from healthy nonsmokers and COPDs
Interventions
- DRUG Hyperpolarized Helium-3
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2010-02 |
| Est. Completion | 2015-03 |
Why NCT02734368 stopped before completion
NCT02734368 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 53 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Hyperpolarized Helium-3 is the first listed.
NCT02734368 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02734368 about?
NCT02734368 is a clinical study titled "A Prospective, Cohort Study of Hyperpolarized 3He MRI in Chronic Obstructive Pulmonary Disease". The purpose of this study is to determine the MRI characteristics of Chronic Obstructive Pulmonary Disease subjects both at baseline and yearly for a period of 5 years, and to correlate these biomarkers with pulmonary function tests, CT scan, 6 Minute-walk tests, and respiratory questionnaires. The...
What is the current status of trial NCT02734368?
This trial is currently terminated. The enrollment target is 53 participants. The study started on 2010-02. Estimated completion is 2015-03.
What interventions are being tested in trial NCT02734368?
The interventions under investigation include: Hyperpolarized Helium-3 (DRUG).
Who is sponsoring clinical trial NCT02734368?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
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