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NCT02731638 · ClinicalTrials.gov registry record · Phase 3
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
A Phase 3 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 3
- Development phase
- 70
- Enrollment target
NCT02731638: Completed Phase 3 study, sponsored by University of California, San Francisco.
NCT02731638 is a Phase 3 study that has completed, run by University of California, San Francisco. The registered enrollment target is 70 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02731638, a Phase 3 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 70 participants
- Enrollment target
Study Summary
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers. There is currently little evidence to guide the treatment of fungal keratitis beyond topical anti-fungal drops, though intrastromal voriconazole and oral antifungal treatments are used as well. This study will provide evidence to guide the treatment of fungal keratitis in the future. The purpose of this study is to determine differences in microbiological cure for 3-day repeat cultures between different antifungal treatments. For this study, there will be 1:1 randomization to one of these two treatment groups: 1) topical natamycin plus intrastromal voriconazole injection or 2) topical natamycin alone.
Primary Outcome
Number of of participants with positive fungal cultures at 3 days
Interventions
- DRUG Natamycin
- DRUG Intrastromal voriconazole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2016-09 |
| Est. Completion | 2018-07 |
| Phase | Phase 3 |
What the finished NCT02731638 record still lists
NCT02731638 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 2 interventions - of which Natamycin is the first listed.
NCT02731638 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02731638 about?
NCT02731638 is a clinical study titled "Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers". Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers. There is currently little evidence to guide the treatment of fungal keratitis beyond topical anti-fungal drops, though ...
What is the current status of trial NCT02731638?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 70 participants. The study started on 2016-09. Estimated completion is 2018-07.
What interventions are being tested in trial NCT02731638?
The interventions under investigation include: Natamycin (DRUG), Intrastromal voriconazole (DRUG).
Who is sponsoring clinical trial NCT02731638?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02731638's enrollment target sits among peer trials
70 1785th of 2000 higher than 208 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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