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NCT02727686 · ClinicalTrials.gov registry record · NA
Post-Operative Water Load Following Transsphenoidal Pituitary Surgery
A NA study, sponsored by St. Joseph's Hospital and Medical Center, Phoenix.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT02727686: Completed NA study, sponsored by St. Joseph's Hospital and Medical Center, Phoenix.
NCT02727686 is a NA study that has completed, run by St. Joseph's Hospital and Medical Center, Phoenix. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02727686, a NA study, has completed, sponsored by St. Joseph's Hospital and Medical Center, Phoenix.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Delayed post-operative hyponatremia occurs in 5-20% of patients following pituitary surgery and typically occurs on post-operative day 5-10.This decline in sodium can occur rapidly and have serious consequences such as altered mental status, seizures, coma, and even death. Despite significant research into patient demographics and risk factors, the investigators have not been able to predict which patients will suffer from delayed post-operative hyponatremia to date. At the Barrow Neurological Institute, physicians currently utilize an outpatient screening protocol to monitor patients' sodium levels after surgery, but this has yet to be effective for reducing readmissions following pituitary surgery. The etiology of delayed post-operative hyponatremia has been linked to water and sodium dysregulation in the post-operative period. It has been shown that post-operative day 1-2 sodium levels are statistically lower in patients who develop delayed hyponatremia, however, the numerical differences are not large enough to guide clinical management. The investigators propose that a water load on post-operative day 1 may expose underlying sodium/water dysregulation in the early post-operative period. This would improve physicians' understanding of the pathophysiology of post-operative hyponatremia, and it may help to serve as a screening tool for these patients in the future.
Primary Outcome
Evaluate patients' responses to water load on the morning of post-operative day 1: serum sodium (normal range 135-145 mmol/L)
Interventions
- OTHER Water Load (WL) Post-Operative Day 1
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2016-03-07 |
| Est. Completion | 2018-12-13 |
| Phase | NA |
What the finished NCT02727686 record still lists
NCT02727686 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Water Load (WL) Post-Operative Day 1 is the first listed.
NCT02727686 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02727686 about?
NCT02727686 is a clinical study titled "Post-Operative Water Load Following Transsphenoidal Pituitary Surgery". Delayed post-operative hyponatremia occurs in 5-20% of patients following pituitary surgery and typically occurs on post-operative day 5-10.This decline in sodium can occur rapidly and have serious consequences such as altered mental status, seizures, coma, and even death. Despite significant resear...
What is the current status of trial NCT02727686?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2016-03-07. Estimated completion is 2018-12-13.
What interventions are being tested in trial NCT02727686?
The interventions under investigation include: Water Load (WL) Post-Operative Day 1 (OTHER).
Who is sponsoring clinical trial NCT02727686?
This trial is sponsored by St. Joseph's Hospital and Medical Center, Phoenix, which has 44 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02727686's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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