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NCT02718573 · ClinicalTrials.gov registry record
Impact of Interferon-free Treatment for Hepatitis C Virus (HCV) on Blood Cells and Factors in Blood
A clinical trial, sponsored by Icahn School of Medicine at Mount Sinai.
- Completed
- Registry status
- 74
- Enrollment target
NCT02718573: Completed study, sponsored by Icahn School of Medicine at Mount Sinai.
NCT02718573 is a clinical trial that has completed, run by Icahn School of Medicine at Mount Sinai. The registered enrollment target is 74 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02718573 has completed, sponsored by Icahn School of Medicine at Mount Sinai.
- COMPLETED
- Registry status
- 74 participants
- Enrollment target
Study Summary
The objectives of the study are to determine the impact of interferon-free treatment for the hepatitis C virus (HCV) on peripheral blood immune cell phenotype and soluble immune-related proteins in blood, while controlling for genetic polymorphisms known to impact HCV-related immune responses, and to determine the impact of the therapy on the emergence of drug-resistant HCV. The study design is informed by the researchers recent investigations of patients receiving HCV treatment. About 4% of patients who had not undergone liver transplantation experienced hepatic decompensating or another serious event. There were several cases of bacterial infection and two cases with elevated markers of autoimmune processes. These events suggest that treatment altered immune responses. About 25% of patients who had undergone liver transplantation experienced hepatic decompensating or another serious adverse event. The long term goal is to understand the pathophysiology of these complications and determine whether HCV treatment can cause an immune reconstitution syndrome in susceptible patients, while improving antimicrobial defenses in others
Primary Outcome
the profile of immune cells in blood as assessed by cytometry time of flight (CyTOF) multiparameter analysis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2015-01 |
| Est. Completion | 2017-12-11 |
What the finished NCT02718573 record still lists
NCT02718573 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 74 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT02718573 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02718573 about?
NCT02718573 is a clinical study titled "Impact of Interferon-free Treatment for Hepatitis C Virus (HCV) on Blood Cells and Factors in Blood". The objectives of the study are to determine the impact of interferon-free treatment for the hepatitis C virus (HCV) on peripheral blood immune cell phenotype and soluble immune-related proteins in blood, while controlling for genetic polymorphisms known to impact HCV-related immune responses, and t...
What is the current status of trial NCT02718573?
This trial is currently completed. The enrollment target is 74 participants. The study started on 2015-01. Estimated completion is 2017-12-11.
Who is sponsoring clinical trial NCT02718573?
This trial is sponsored by Icahn School of Medicine at Mount Sinai, which has 708 total clinical trials registered on ClinicalTrials.gov.
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