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NCT02702115 · ClinicalTrials.gov registry record · Phase 1
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I
A Phase 1 study, sponsored by Sangamo Therapeutics.
- Terminated
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
NCT02702115 is a Phase 1 study that was terminated before completion, run by Sangamo Therapeutics. The registered enrollment target is 3 participants.
The verdict
NCT02702115, a Phase 1 study, was terminated before completion, sponsored by Sangamo Therapeutics.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
The purpose of the study is to evaluate the safety, tolerability of ascending doses of SB-318. SB-318 is an intravenously delivered Zinc Finger Nuclease (ZFN) Therapeutic for genome editing. It inserts a correct copy of the α-L-iduronidase (IDUA) gene into the Albumin locus in hepatocytes with the goal of lifelong therapeutic production of the IDUA enzyme.
Interventions
- BIOLOGICAL SB-318
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2017-05-24 |
| Est. Completion | 2021-11-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02702115
The ClinicalTrials.gov registry entry for NCT02702115 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 3 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sangamo Therapeutics, which has 25 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which SB-318 is the first listed.
NCT02702115 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02702115 about?
NCT02702115 is a clinical study titled "Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I". The purpose of the study is to evaluate the safety, tolerability of ascending doses of SB-318. SB-318 is an intravenously delivered Zinc Finger Nuclease (ZFN) Therapeutic for genome editing. It inserts a correct copy of the α-L-iduronidase (IDUA) gene into the Albumin locus in hepatocytes with the g...
What is the current status of trial NCT02702115?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2017-05-24. Estimated completion is 2021-11-03.
What interventions are being tested in trial NCT02702115?
The interventions under investigation include: SB-318 (BIOLOGICAL).
Who is sponsoring clinical trial NCT02702115?
This trial is sponsored by Sangamo Therapeutics, which has 25 total clinical trials registered on ClinicalTrials.gov.
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