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NCT02696980 · ClinicalTrials.gov registry record · Phase 1
PEEP as Rescue Therapy for Asthmatics With Elevated BMI
A Phase 1 study, sponsored by University of Vermont.
- Completed
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
NCT02696980: Completed Phase 1 study, sponsored by University of Vermont.
NCT02696980 is a Phase 1 study that has completed, run by University of Vermont. The registered enrollment target is 18 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02696980, a Phase 1 study, has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
Study Summary
The purpose of this study is to test the effect of increasing lung volume with a simple hand-held device to both prevent, and also to relieve, airway constriction in people with asthma and a BMI ≥ 30 kg/m2. Twenty people with late onset non-allergic asthma and a BMI of ≥ 30 kg/m2 will be recruited. The efficacy of elevating lung volume on both preventing and reversing bronchoconstriction will be tested. Lung volume will be modulated by breathing out against a small level of resistance (positive expiratory pressure).
Primary Outcome
Investigators compare changes in respiratory system elastance to methacholine. Respiratory system impedance was measured at the 8-min time point and fit with the two-compartment series model of respiratory mechanics. The elastances of the central and distal compartments obtained from good quality fits of this model are reported for each of the following conditions: V2: PEP of 0 was administered during (0-4.5 min) and after (4.5-8 min) methacholine administration. V3: PEP of 0 was administered
Interventions
- DEVICE Positive Expiratory Pressure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2016-04 |
| Est. Completion | 2019-06 |
| Phase | Phase 1 |
What the finished NCT02696980 record still lists
NCT02696980 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 1 intervention - of which Positive Expiratory Pressure is the first listed.
NCT02696980 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02696980 about?
NCT02696980 is a clinical study titled "PEEP as Rescue Therapy for Asthmatics With Elevated BMI". The purpose of this study is to test the effect of increasing lung volume with a simple hand-held device to both prevent, and also to relieve, airway constriction in people with asthma and a BMI ≥ 30 kg/m2. Twenty people with late onset non-allergic asthma and a BMI of ≥ 30 kg/m2 will be recruited....
What is the current status of trial NCT02696980?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2016-04. Estimated completion is 2019-06.
What interventions are being tested in trial NCT02696980?
The interventions under investigation include: Positive Expiratory Pressure (DEVICE).
Who is sponsoring clinical trial NCT02696980?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02696980's enrollment target sits among peer trials
18 1720th of 2000 higher than 216 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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