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NCT02688179 · ClinicalTrials.gov registry record
Neuroinflammation and Postoperative Delirium in Cardiac Surgery
A clinical trial, sponsored by Vanderbilt University.
- Completed
- Registry status
- 630
- Enrollment target
NCT02688179: Completed study, sponsored by Vanderbilt University.
NCT02688179 is a clinical trial that has completed, run by Vanderbilt University. The registered enrollment target is 630 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02688179 has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- 630 participants
- Enrollment target
Study Summary
Up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. Delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of Alzheimer's disease. The underlying mechanisms behind delirium are not understood, and therefore the current prevention and treatment strategies are inadequate. Several hypotheses exist for the pathophysiology of delirium, one of which is the role of neuroinflammation. The stress associated with high-risk procedures such as cardiac surgery may lead to systemic inflammation causing endothelial dysfunction and disruption of the blood brain barrier (BBB). When this occurs, the brain is susceptible to neuronal injury via neuroinflammation after which a state of delirium may ensue. To characterize the mechanisms of neuroinflammation in delirium, the investigators will explore the biomarkers most closely linked to each step of the proposed pathway.
Primary Outcome
biomarker of endothelial dysfunction to be measured at 3 time points
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 630 participants |
| Start Date | 2016-01 |
| Est. Completion | 2017-03 |
What the finished NCT02688179 record still lists
NCT02688179 is an observational study that tracks outcomes without assigning an intervention. The registered 630 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT02688179 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02688179 about?
NCT02688179 is a clinical study titled "Neuroinflammation and Postoperative Delirium in Cardiac Surgery". Up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. Delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of Alzheimer's disease. The underlying mechanisms behind delirium are not ...
What is the current status of trial NCT02688179?
This trial is currently completed. The enrollment target is 630 participants. The study started on 2016-01. Estimated completion is 2017-03.
Who is sponsoring clinical trial NCT02688179?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
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