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NCT02688179 · ClinicalTrials.gov registry record
Neuroinflammation and Postoperative Delirium in Cardiac Surgery
A clinical trial, sponsored by Vanderbilt University.
- Completed
- Registry status
- 630
- Enrollment target
NCT02688179 is a clinical trial that has completed, run by Vanderbilt University. The registered enrollment target is 630 participants.
The verdict
NCT02688179 has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- 630 participants
- Enrollment target
Study Summary
Up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. Delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of Alzheimer's disease. The underlying mechanisms behind delirium are not understood, and therefore the current prevention and treatment strategies are inadequate. Several hypotheses exist for the pathophysiology of delirium, one of which is the role of neuroinflammation. The stress associated with high-risk procedures such as cardiac surgery may lead to systemic inflammation causing endothelial dysfunction and disruption of the blood brain barrier (BBB). When this occurs, the brain is susceptible to neuronal injury via neuroinflammation after which a state of delirium may ensue. To characterize the mechanisms of neuroinflammation in delirium, the investigators will explore the biomarkers most closely linked to each step of the proposed pathway.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 630 participants |
| Start Date | 2016-01 |
| Est. Completion | 2017-03 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02688179
The ClinicalTrials.gov registry entry for NCT02688179 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 630 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University, which has 430 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT02688179 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02688179 about?
NCT02688179 is a clinical study titled "Neuroinflammation and Postoperative Delirium in Cardiac Surgery". Up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. Delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of Alzheimer's disease. The underlying mechanisms behind delirium are not ...
What is the current status of trial NCT02688179?
This trial is currently completed. The enrollment target is 630 participants. The study started on 2016-01. Estimated completion is 2017-03.
Who is sponsoring clinical trial NCT02688179?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
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