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NCT02654925 · ClinicalTrials.gov registry record
Myeloid to Adipocyte Transdifferentiation in Human Cells
A clinical trial, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 59
- Enrollment target
NCT02654925 is a clinical trial that has completed, run by University of Colorado, Denver. The registered enrollment target is 59 participants.
The verdict
NCT02654925 has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 59 participants
- Enrollment target
Study Summary
In order to design new programs to help prevent weight gain, promote successful and sustainable weight loss, and help treat diseases related to obesity, the investigators need a better understanding of why accumulating fat in certain regions of the body is bad for health. It is known that not all fat cells are the same, but it was recently discovered that some fat cells may arise from stem cells that come from the bone marrow (bone marrow progenitors), a previously unrecognized origin. This discovery has been paradigm shifting, because dogma has long held that all white fat cells arise from fat tissue resident mesenchymal stem cells. This is also important because fat cells arising from the bone marrow lineage may be linked to worse health outcomes. The aim of this study is to determine if cells that were not previously believed to contribute to fat generation in humans are indeed capable of becoming fat cells. To answer this question the investigators will take samples of cells from the blood and the fat tissue of younger and older men and women, isolate the cells that came from the bone marrow and grow them in culture to determine if they will turn into fat cells. The results of this investigation may reveal potential mechanistic targets for future therapies to reduce the negative health outcomes associated with obesity related chronic diseases.
Interventions
- PROCEDURE Adipose Tissue Biopsy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2016-03 |
| Est. Completion | 2021-06-15 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02654925
The ClinicalTrials.gov registry entry for NCT02654925 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Adipose Tissue Biopsy is the first listed.
NCT02654925 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02654925 about?
NCT02654925 is a clinical study titled "Myeloid to Adipocyte Transdifferentiation in Human Cells". In order to design new programs to help prevent weight gain, promote successful and sustainable weight loss, and help treat diseases related to obesity, the investigators need a better understanding of why accumulating fat in certain regions of the body is bad for health. It is known that not all fa...
What is the current status of trial NCT02654925?
This trial is currently completed. The enrollment target is 59 participants. The study started on 2016-03. Estimated completion is 2021-06-15.
What interventions are being tested in trial NCT02654925?
The interventions under investigation include: Adipose Tissue Biopsy (PROCEDURE).
Who is sponsoring clinical trial NCT02654925?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
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