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NCT02581111 · ClinicalTrials.gov registry record · Phase 2
Naloxone for Optimizing Hypoxemia Of Lung Donors
A Phase 2 study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 2
- Development phase
- 199
- Enrollment target
NCT02581111: Completed Phase 2 study, sponsored by Washington University School of Medicine.
NCT02581111 is a Phase 2 study that has completed, run by Washington University School of Medicine. The registered enrollment target is 199 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (50% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02581111, a Phase 2 study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 199 participants
- Enrollment target
Study Summary
Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals hypoxemia, as defined by the ratio of partial pressure of oxygen in arterial blood (PaO2) to fraction of inspired oxygen (FiO2) below 300 mm Hg, unless they have already been ruled-out for lung recovery. Investigators aim to assess whether naloxone improves oxygenation prior to organ recovery more than placebo.
Primary Outcome
Change in ratio of partial pressure of oxygen in arterial blood (PaO2) to fraction of inspired oxygen (FiO2) from final ABG performed before organ recovery compared to baseline ABG
Interventions
- DRUG Normal saline
- DRUG Naloxone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 199 participants |
| Start Date | 2015-09 |
| Est. Completion | 2017-09-25 |
| Phase | Phase 2 |
What the finished NCT02581111 record still lists
NCT02581111 is an interventional study that assigns participants to a tested intervention. The registered 199 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (50% higher).
The record links to 0 conditions, and to 2 interventions - of which Normal saline is the first listed.
NCT02581111 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02581111 about?
NCT02581111 is a clinical study titled "Naloxone for Optimizing Hypoxemia Of Lung Donors". Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals hypoxemia, as defined by the ratio of partial pressure of oxygen in arterial blo...
What is the current status of trial NCT02581111?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 199 participants. The study started on 2015-09. Estimated completion is 2017-09-25.
What interventions are being tested in trial NCT02581111?
The interventions under investigation include: Normal saline (DRUG), Naloxone (DRUG).
Who is sponsoring clinical trial NCT02581111?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02581111's enrollment target sits among peer trials
199 349th of 2000 higher than 1,652 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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