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NCT02569034 · ClinicalTrials.gov registry record · NA
Dissociating Components of Anhedonia: A Pilot fMRI Study
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 46
- Enrollment target
NCT02569034 is a NA study that has completed, run by University of Florida. The registered enrollment target is 46 participants.
The verdict
NCT02569034, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 46 participants
- Enrollment target
Study Summary
Anhedonia, decreased motivation for and sensitivity to rewarding experiences, is present in at least 1/3 of community dwelling older adults and is a feature of various psychiatric and neurological disorders, including late-life depression and Parkinson's disease. Anhedonia is associated with cognitive deficits, as well as poor clinical outcomes and increased mortality. Recent research suggests that anhedonia comprises motivational (reward "wanting") and consummatory (reward "liking") aspects. However, previous research on anhedonia has failed to dissociate these components, which may explain the contradictory findings in the literature. Recently, the Effort-Expenditure for Rewards Task (EEfRT) was developed in an effort to dissociate reward components in anhedonia. The EEfRT is an effort-based decision-making task that measures reward "wanting", in contrast to commonly used anhedonia questionnaires, which focus on reward "liking." This novel task may provide a useful measure of components of anhedonia in older adults and in different patient populations. Thus far no data is available on this task in elderly individuals, and the cognitive and neural correlates of components of the task have not been investigated. Given the paucity of research on the neurobiology of anhedonia, cognitive neuroscience studies using this task could fill a gap in the literature. The investigators are developing a line of cognitive neuroscience studies examining anhedonia in community-dwelling older adults and in late-life depression and Parkinson's disease. This study will involve gathering pilot behavioral and functional magnetic resonance imaging (fMRI) data in young and older adults performing the EEfRT task. Understanding the brain mechanisms underlying anhedonia in older adults and in different patient populations will have a translational impact by elucidating biological targets for treatment.
Interventions
- OTHER Functional Magnetic Resonance Imaging
- OTHER Effort-Expenditure for Rewards Task
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2016-02 |
| Est. Completion | 2018-05-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02569034
The ClinicalTrials.gov registry entry for NCT02569034 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Florida, which has 1,106 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Functional Magnetic Resonance Imaging is the first listed.
NCT02569034 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02569034 about?
NCT02569034 is a clinical study titled "Dissociating Components of Anhedonia: A Pilot fMRI Study". Anhedonia, decreased motivation for and sensitivity to rewarding experiences, is present in at least 1/3 of community dwelling older adults and is a feature of various psychiatric and neurological disorders, including late-life depression and Parkinson's disease. Anhedonia is associated with cogniti...
What is the current status of trial NCT02569034?
This trial is currently completed. It is a NA study. The enrollment target is 46 participants. The study started on 2016-02. Estimated completion is 2018-05-08.
What interventions are being tested in trial NCT02569034?
The interventions under investigation include: Functional Magnetic Resonance Imaging (OTHER), Effort-Expenditure for Rewards Task (OTHER).
Who is sponsoring clinical trial NCT02569034?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
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