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NCT02568410 · ClinicalTrials.gov registry record
Platelets as Regulators of Inflammation in Cardiac Surgery
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 99
- Enrollment target
NCT02568410: Completed study, sponsored by Duke University.
NCT02568410 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 99 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02568410 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 99 participants
- Enrollment target
Study Summary
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in cardiac surgery patients. However, in current practice, concerns of excessive bleeding-not platelet activation and thrombosis-shape clinical decisions. The investigators have recently seen, that a significant drop in platelet numbers following cardiac surgery is associated with increased mortality and risk of acute kidney injury. The investigators hypothesize that such thrombocytopenia is a result of excessive perioperative platelet activation and resultant release of inflammatory and tissue injurious signals by activated platelets. Platelet activation will be characterized during and after cardiac surgery and examine its correlation with inflammatory responses and perioperative end-organ injury.
Primary Outcome
AKI according to KDIGO criteria
Interventions
- PROCEDURE coronary artery bypass grafting using cardiopulmonary bypass
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 99 participants |
| Start Date | 2015-10 |
| Est. Completion | 2019-05 |
What the finished NCT02568410 record still lists
NCT02568410 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 99 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which coronary artery bypass grafting using cardiopulmonary bypass is the first listed.
NCT02568410 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02568410 about?
NCT02568410 is a clinical study titled "Platelets as Regulators of Inflammation in Cardiac Surgery". Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in cardiac surgery patients. However, in current practice, concerns of exce...
What is the current status of trial NCT02568410?
This trial is currently completed. The enrollment target is 99 participants. The study started on 2015-10. Estimated completion is 2019-05.
What interventions are being tested in trial NCT02568410?
The interventions under investigation include: coronary artery bypass grafting using cardiopulmonary bypass (PROCEDURE).
Who is sponsoring clinical trial NCT02568410?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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