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NCT02524145 · ClinicalTrials.gov registry record · NA
Chronotropic Incompetence in Patients With HFpEF
A NA study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT02524145: Completed NA study, sponsored by University of Texas Southwestern Medical Center.
NCT02524145 is a NA study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02524145, a NA study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the mechanisms of chronotropic incompetence (inability to increase heart rate with exercise) in patients with heart failure and preserved ejection fraction (HFpEF). The investigators will test both central command regulation and cardiac beta-receptor sensitivity over control of heart rate.
Primary Outcome
Cardiac beta-receptor sensitivity will be measured by calculating slope of heart rate versus isoproterenol serum level.
Interventions
- DRUG Isoproterenol
- DRUG Dexmedetomidine
- DRUG Glycopyrrolate
- OTHER Static Handgrip
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2015-06 |
| Est. Completion | 2017-11-15 |
| Phase | NA |
What the finished NCT02524145 record still lists
NCT02524145 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 4 interventions - of which Isoproterenol is the first listed.
NCT02524145 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02524145 about?
NCT02524145 is a clinical study titled "Chronotropic Incompetence in Patients With HFpEF". The purpose of this study is to determine the mechanisms of chronotropic incompetence (inability to increase heart rate with exercise) in patients with heart failure and preserved ejection fraction (HFpEF). The investigators will test both central command regulation and cardiac beta-receptor sensiti...
What is the current status of trial NCT02524145?
This trial is currently completed. It is a NA study. The enrollment target is 40 participants. The study started on 2015-06. Estimated completion is 2017-11-15.
What interventions are being tested in trial NCT02524145?
The interventions under investigation include: Isoproterenol (DRUG), Dexmedetomidine (DRUG), Glycopyrrolate (DRUG), Static Handgrip (OTHER).
Who is sponsoring clinical trial NCT02524145?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02524145's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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