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NCT02515890 · ClinicalTrials.gov registry record · Phase 1
Memory Modulation by Pain During Anesthesia
A Phase 1 study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- Phase 1
- Development phase
- 32
- Enrollment target
NCT02515890: Completed Phase 1 study, sponsored by University of Pittsburgh.
NCT02515890 is a Phase 1 study that has completed, run by University of Pittsburgh. The registered enrollment target is 32 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (47% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02515890, a Phase 1 study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 32 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.
Primary Outcome
Subjects completed the Remember, Know, New (RKN) task during next day testing. Their d' memory score was calculated based on their ability to discriminate between previously heard words and new words. A higher d' score indicates stronger recollection. D' scores were compared across the control condition (saline) and the drug conditions dexmedetomidine, midazolam, and ketamine. Performance was also calculated according to words associated with Pain and No Pain conditions.
Interventions
- DRUG Ketamine
- DRUG Midazolam
- DRUG Dexmedetomidine
- DEVICE Peripheral nerve stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2015-11-19 |
| Est. Completion | 2018-12-12 |
| Phase | Phase 1 |
What the finished NCT02515890 record still lists
NCT02515890 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (47% lower).
The record links to 0 conditions, and to 4 interventions - of which Ketamine is the first listed.
NCT02515890 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02515890 about?
NCT02515890 is a clinical study titled "Memory Modulation by Pain During Anesthesia". The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, fu...
What is the current status of trial NCT02515890?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 32 participants. The study started on 2015-11-19. Estimated completion is 2018-12-12.
What interventions are being tested in trial NCT02515890?
The interventions under investigation include: Ketamine (DRUG), Midazolam (DRUG), Dexmedetomidine (DRUG), Peripheral nerve stimulation (DEVICE).
Who is sponsoring clinical trial NCT02515890?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02515890's enrollment target sits among peer trials
32 1296th of 2000 higher than 679 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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