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NCT02514798 · ClinicalTrials.gov registry record · NA
Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing
A NA study, sponsored by Tufts Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT02514798 is a NA study that has completed, run by Tufts Medical Center. The registered enrollment target is 11 participants.
The verdict
NCT02514798, a NA study, has completed, sponsored by Tufts Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
Patients affected with severe parenchymal pulmonary diseases, such as Chronic Obstructive Pulmonary Disease (COPD ), may experience dyspnea at rest due to increased work of breathing and reduced oxygenation. The delivery of high-flow humidified nasal oxygen (HFNC) has been shown to have a positive-end-expiratory pressure (PEEP) effect and is able to flush out CO2 from the upper airways, reducing dead space ventilation. Furthermore it has been proven to reduce the respiratory rate shortly after its initiation. These multiple actions offer the potential of changing the respiratory pattern and reducing work of breathing, improving the efficiency of breathing. In this short-term, physiological, open, randomized, cross-over pilot study the investigator swill describe the effects of varying settings of high-flow nasal oxygen on respiratory rate, tidal volume, and diaphragmatic work of breathing in patients with severe COPD. The investigators will also describe changes in gas exchange and effects on the subjects' comfort and dyspnea and the breathing responses to varying setting of CPAP in the subject population.
Interventions
- OTHER Esophageal and gastric balloons
- OTHER Respiratory Inductance Plethysmography (RIP) system
- OTHER Sentec transcutaneous monitoring system
- DEVICE High-flow humidified nasal oxygen delivery system
- DEVICE CPAP (Positive Control)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2015-07 |
| Est. Completion | 2018-04-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02514798
The ClinicalTrials.gov registry entry for NCT02514798 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tufts Medical Center, which has 169 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Esophageal and gastric balloons is the first listed.
NCT02514798 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02514798 about?
NCT02514798 is a clinical study titled "Pilot Study of Physiological Effect of High-Flow Nasal Cannula on Respiratory Pattern and Work of Breathing". Patients affected with severe parenchymal pulmonary diseases, such as Chronic Obstructive Pulmonary Disease (COPD ), may experience dyspnea at rest due to increased work of breathing and reduced oxygenation. The delivery of high-flow humidified nasal oxygen (HFNC) has been shown to have a positive-e...
What is the current status of trial NCT02514798?
This trial is currently completed. It is a NA study. The enrollment target is 11 participants. The study started on 2015-07. Estimated completion is 2018-04-01.
What interventions are being tested in trial NCT02514798?
The interventions under investigation include: Esophageal and gastric balloons (OTHER), Respiratory Inductance Plethysmography (RIP) system (OTHER), Sentec transcutaneous monitoring system (OTHER), High-flow humidified nasal oxygen delivery system (DEVICE), CPAP (Positive Control) (DEVICE).
Who is sponsoring clinical trial NCT02514798?
This trial is sponsored by Tufts Medical Center, which has 169 total clinical trials registered on ClinicalTrials.gov.
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