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NCT02499757 · ClinicalTrials.gov registry record · Phase 1
Does Sweet Taste Potentiate Nicotine Cue Reactivity?
A Phase 1 study, sponsored by Yale University.
- Completed
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
NCT02499757: Completed Phase 1 study, sponsored by Yale University.
NCT02499757 is a Phase 1 study that has completed, run by Yale University. The registered enrollment target is 15 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02499757, a Phase 1 study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
Study Summary
The investigators' aim is to test the prediction that sweet taste perception enhances the ability of nicotine to induce neural plastic changes in brain reward circuits to increase the saliency, liking and brain reactivity to the sight and vaporized flavor of electronic cigarettes (e-cigarettes).
Primary Outcome
At baseline and 2 days post exposure, subjects will rate 'liking' using the general Labeled Hedonic Scale (LHS). The LHS is a vertical line scale with quasi-logarithmic spaced, with the label 'most imaginable dislike' in the bottom to 'most imaginable like' in the top, with the label 'neutral' in the middle (recoded to range of -100 to +100).
Interventions
- DEVICE flavor and sweetener
- DEVICE flavor and nicotine
- DEVICE flavor, nicotine and sweetener
- DEVICE flavor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2015-05 |
| Est. Completion | 2015-11 |
| Phase | Phase 1 |
What the finished NCT02499757 record still lists
NCT02499757 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower).
The record links to 0 conditions, and to 4 interventions - of which flavor and sweetener is the first listed.
NCT02499757 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02499757 about?
NCT02499757 is a clinical study titled "Does Sweet Taste Potentiate Nicotine Cue Reactivity?". The investigators' aim is to test the prediction that sweet taste perception enhances the ability of nicotine to induce neural plastic changes in brain reward circuits to increase the saliency, liking and brain reactivity to the sight and vaporized flavor of electronic cigarettes (e-cigarettes).
What is the current status of trial NCT02499757?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2015-05. Estimated completion is 2015-11.
What interventions are being tested in trial NCT02499757?
The interventions under investigation include: flavor and sweetener (DEVICE), flavor and nicotine (DEVICE), flavor, nicotine and sweetener (DEVICE), flavor (DEVICE).
Who is sponsoring clinical trial NCT02499757?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02499757's enrollment target sits among peer trials
15 1798th of 2000 higher than 157 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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