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NCT02499705 · ClinicalTrials.gov registry record · NA
The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents
A NA study, sponsored by Yale University.
- Terminated
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT02499705: Clinical Trial NA study, sponsored by Yale University.
NCT02499705 is a NA study that was terminated before completion, run by Yale University. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02499705, a NA study, was terminated before completion, sponsored by Yale University.
- TERMINATED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adolescents using fMRI, psychophysical measures, and questionnaires. The investigators hypothesize that dietary exposure to artificial sweeteners (sucralose) will decrease sensitivity to taste, shift preference of sweet and savory taste to a higher dose, and reduce brain response in amygdala to sweet taste compared to sucrose.
Primary Outcome
At baseline and after on average 2 weeks, subjects will rate intensity of sucrose, sucralose, mono potassium glutamate, sodium chloride and citric acid using the General Labeled Magnitude Scale (gLMS). It is a vertical line with quasi-logarithmic spaced labels that start at the bottom with 'barely detectable' to 'strongest imaginable' at the top, recoded to 0-100.
Interventions
- DIETARY_SUPPLEMENT Sucrose
- DIETARY_SUPPLEMENT Sucralose
- DIETARY_SUPPLEMENT Sucralose + maltodextrin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2014-11 |
| Est. Completion | 2017-12 |
| Phase | NA |
Why NCT02499705 stopped before completion
NCT02499705 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Sucrose is the first listed.
NCT02499705 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02499705 about?
NCT02499705 is a clinical study titled "The Effect of Artificial Sweeteners (AFS) on Sweetness Sensitivity, Preference and Brain Response in Adolescents". The purpose of this study is to investigate the effects of dietary exposure to artificial sweeteners on taste sensitivity, preference and brain response in adolescents using fMRI, psychophysical measures, and questionnaires. The investigators hypothesize that dietary exposure to artificial sweetener...
What is the current status of trial NCT02499705?
This trial is currently terminated. It is a NA study. The enrollment target is 15 participants. The study started on 2014-11. Estimated completion is 2017-12.
What interventions are being tested in trial NCT02499705?
The interventions under investigation include: Sucrose (DIETARY_SUPPLEMENT), Sucralose (DIETARY_SUPPLEMENT), Sucralose + maltodextrin (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02499705?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02499705's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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