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NCT02488863 · ClinicalTrials.gov registry record
NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
A clinical trial, sponsored by University of Florida.
- Completed
- Registry status
- 105
- Enrollment target
NCT02488863: Completed study, sponsored by University of Florida.
NCT02488863 is a clinical trial that has completed, run by University of Florida. The registered enrollment target is 105 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02488863 has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- 105 participants
- Enrollment target
Study Summary
Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly account for the presence, absence, or severity of chronic musculoskeletal pain (CMP). Recent studies show that individuals with CMP exhibit dysfunctional pain modulation supporting a significant central nervous system (CNS) contribution. However, the CNS mechanisms underlying these changes in pain modulation are not currently known, nor is their relation to clinical pain progression. The proposed pilot examines brain circuits recently described in predicting the transition from acute to chronic pain, in predicting clinical and experimental pain changes as well as physical performance and mobility changes in older persons with musculoskeletal pain over a one year period. The findings will provide novel and important information regarding the mechanisms underlying aberrant pain processing and its functional consequences in older adults with musculoskeletal pain. The information learned can be subsequently used to target treatment and prevention strategies in future studies of older adults. The central hypothesis is that increased functional and structural connectivity of cortico-striatal regions will be significantly associated with baseline clinical and experimental pain and decreased physical function in persons with CMP and will account for more rapid clinical pain and disability progression over time.
Primary Outcome
The Short Physical Performance Battery (SPPB) Total Score is a measure of physical function. It is calculated by summing three measures of lower-extremity function: standing balance (side-by-side, semi-tandem, and tandem stance), 4-meter walking speed, and ability to rise from a chair. Each task is rated on a 0-4 scale, with increasing scores indicating better physical performance. The SPPB Total scores range from 0-12.
Interventions
- OTHER Questionnaires
- OTHER Quantitative Sensory Testing
- OTHER MRI Neuroimaging
- OTHER Physical and Cognitive Function Testing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2015-07 |
| Est. Completion | 2024-02-04 |
What the finished NCT02488863 record still lists
NCT02488863 is an observational study that tracks outcomes without assigning an intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 4 interventions - of which Questionnaires is the first listed.
NCT02488863 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02488863 about?
NCT02488863 is a clinical study titled "NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)". Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly account for the presence, absence, or severity of chronic musculoskele...
What is the current status of trial NCT02488863?
This trial is currently completed. The enrollment target is 105 participants. The study started on 2015-07. Estimated completion is 2024-02-04.
What interventions are being tested in trial NCT02488863?
The interventions under investigation include: Questionnaires (OTHER), Quantitative Sensory Testing (OTHER), MRI Neuroimaging (OTHER), Physical and Cognitive Function Testing (OTHER).
Who is sponsoring clinical trial NCT02488863?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
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