Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]
NCT02486718 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with Stage IB-Stage IIIA non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy, as measured by disease-free survival (DFS) as assessed by the investigator and overall survival (OS). Participants, after completing up to 4 cycles of adjuvant cisplatin-based chemotherapy, will be randomized in a 1:1 ratio to receive atezolizumab for 16 cycles or BSC.
Conditions Studied
Interventions
- DRUG Docetaxel
- DRUG Atezolizumab
- DRUG Cisplatin
- DRUG Gemcitabine
- DRUG Vinorelbine
Study Locations (20)
California
- California Cancer Associates for Research & Excellence, Inc. — Encinitas
- Compassionate Cancer Care Medical Group, Inc — Fountain Valley
- University of California Los Angeles — Los Angeles
- Kaiser Permanente — Vallejo
- Kaiser Permanente - Walnut Creek — Walnut Creek
New Jersey
- Hematology Oncology Associates of Northern New Jersey — Florham Park
- Saint Barnabas Medical Center — Livingston
- Valley Hospital — Paramus
- Overlook Medical Center — Summit
Florida
- Lynn Cancer Institute - West — Boca Raton
- University of Miami School of Medicine - Sylvester at Deerfield — Deerfield Beach
- SCRI Florida Cancer Specialists North — St. Petersburg
Illinois
- University of Illinois at Chicago — Chicago
- Illinois Cancer Care — Peoria
Arkansas
- Highlands Oncology Group — Fayetteville
Connecticut
- Eastern Connecticut Hematology and Oncology Associates — Norwich
Georgia
- Lewis Hall Singletary Oncology Center — Thomasville
Kentucky
- Norton Cancer Institute — Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,280 participants |
| Start Date | 2015-10-31 |
| Est. Completion | 2027-08-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02486718
The ClinicalTrials.gov registry entry for NCT02486718 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,280 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02486718 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, New Jersey, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02486718 about?
NCT02486718 is a clinical study titled "Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]". This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with Stage IB-Stage IIIA non-small cell lung cancer (NSCLC)...
What is the current status of trial NCT02486718?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,280 participants. The study started on 2015-10-31. Estimated completion is 2027-08-31.
What conditions does trial NCT02486718 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02486718?
The interventions under investigation include: Docetaxel (DRUG), Atezolizumab (DRUG), Cisplatin (DRUG), Gemcitabine (DRUG), Vinorelbine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02486718?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02486718 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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