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NCT02457702 · ClinicalTrials.gov registry record · NA
Mitochondrial Function in Patients With Severe Liver Disease
A NA study, sponsored by University of Texas Southwestern Medical Center.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT02457702: Clinical Trial NA study, sponsored by University of Texas Southwestern Medical Center.
NCT02457702 is a NA study that was terminated before completion, run by University of Texas Southwestern Medical Center. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02457702, a NA study, was terminated before completion, sponsored by University of Texas Southwestern Medical Center.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of \[U-13C3\]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg). The total dose of glycerol will be 50 mg/kg in 100 milliliters of water. The taste is slightly sweet. Blood will be drawn at 60 min and 120 min after the ingestion. Blood glucose will be isolated and analyzed by NMR. The presence of \[5,6-13C2\]- and \[4,5-13C2\]glucose indicates preserved mitochondrial function. The researchers anticipate that patients with severe liver disease will show a decrease in mitochondrial function and will inform biosynthetic function of liver mitochondria. After the first 6 successful exams (see power analysis, below), healthy volunteers (age-, gender-, and race-matched) will be studied at the AIRC and subject to the same protocol.
Primary Outcome
Once at 60 minutes post ingestion and once at 120 minutes ingestion for a total ot 2 times
Interventions
- OTHER Orally administered labeled glycerol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2015-10 |
| Est. Completion | 2021-12 |
| Phase | NA |
Why NCT02457702 stopped before completion
NCT02457702 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Orally administered labeled glycerol is the first listed.
NCT02457702 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02457702 about?
NCT02457702 is a clinical study titled "Mitochondrial Function in Patients With Severe Liver Disease". The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of \[U-13C3\]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg). The total dose of glycerol will be 50 mg/kg in 100 milliliters of water....
What is the current status of trial NCT02457702?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2015-10. Estimated completion is 2021-12.
What interventions are being tested in trial NCT02457702?
The interventions under investigation include: Orally administered labeled glycerol (OTHER).
Who is sponsoring clinical trial NCT02457702?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02457702's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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