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NCT02457702 · ClinicalTrials.gov registry record · NA
Mitochondrial Function in Patients With Severe Liver Disease
A NA study, sponsored by University of Texas Southwestern Medical Center.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT02457702 is a NA study that was terminated before completion, run by University of Texas Southwestern Medical Center. The registered enrollment target is 2 participants.
The verdict
NCT02457702, a NA study, was terminated before completion, sponsored by University of Texas Southwestern Medical Center.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of \[U-13C3\]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg). The total dose of glycerol will be 50 mg/kg in 100 milliliters of water. The taste is slightly sweet. Blood will be drawn at 60 min and 120 min after the ingestion. Blood glucose will be isolated and analyzed by NMR. The presence of \[5,6-13C2\]- and \[4,5-13C2\]glucose indicates preserved mitochondrial function. The researchers anticipate that patients with severe liver disease will show a decrease in mitochondrial function and will inform biosynthetic function of liver mitochondria. After the first 6 successful exams (see power analysis, below), healthy volunteers (age-, gender-, and race-matched) will be studied at the AIRC and subject to the same protocol.
Interventions
- OTHER Orally administered labeled glycerol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2015-10 |
| Est. Completion | 2021-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02457702
The ClinicalTrials.gov registry entry for NCT02457702 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 2 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Texas Southwestern Medical Center, which has 837 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Orally administered labeled glycerol is the first listed.
NCT02457702 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02457702 about?
NCT02457702 is a clinical study titled "Mitochondrial Function in Patients With Severe Liver Disease". The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of \[U-13C3\]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg). The total dose of glycerol will be 50 mg/kg in 100 milliliters of water....
What is the current status of trial NCT02457702?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2015-10. Estimated completion is 2021-12.
What interventions are being tested in trial NCT02457702?
The interventions under investigation include: Orally administered labeled glycerol (OTHER).
Who is sponsoring clinical trial NCT02457702?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
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