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NCT02452372 · ClinicalTrials.gov registry record · Phase 1
A Phase 1 Study of Givosiran (ALN-AS1) in Patients With Acute Intermittent Porphyria (AIP)
A Phase 1 study, sponsored by Alnylam Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT02452372: Completed Phase 1 study, sponsored by Alnylam Pharmaceuticals.
NCT02452372 is a Phase 1 study that has completed, run by Alnylam Pharmaceuticals. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02452372, a Phase 1 study, has completed, sponsored by Alnylam Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety and tolerability of givosiran (ALN-AS1) in AIP patients as well as to characterize pharmacokinetics (PK) and pharmacodynamics (PD) of ALN-AS1 in AIP patients.
Interventions
- DRUG Sterile Normal Saline (0.9% NaCl)
- DRUG givosiran (ALN-AS1)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2015-05-06 |
| Est. Completion | 2017-09-06 |
| Phase | Phase 1 |
What the finished NCT02452372 record still lists
NCT02452372 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 2 interventions - of which Sterile Normal Saline (0.9% NaCl) is the first listed.
NCT02452372 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02452372 about?
NCT02452372 is a clinical study titled "A Phase 1 Study of Givosiran (ALN-AS1) in Patients With Acute Intermittent Porphyria (AIP)". The purpose of this study is to evaluate the safety and tolerability of givosiran (ALN-AS1) in AIP patients as well as to characterize pharmacokinetics (PK) and pharmacodynamics (PD) of ALN-AS1 in AIP patients.
What is the current status of trial NCT02452372?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2015-05-06. Estimated completion is 2017-09-06.
What interventions are being tested in trial NCT02452372?
The interventions under investigation include: Sterile Normal Saline (0.9% NaCl) (DRUG), givosiran (ALN-AS1) (DRUG).
Who is sponsoring clinical trial NCT02452372?
This trial is sponsored by Alnylam Pharmaceuticals, which has 49 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02452372's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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