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NCT02440815 · ClinicalTrials.gov registry record · NA
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
A NA study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- NA
- Development phase
- 108
- Enrollment target
NCT02440815: Completed NA study, sponsored by University of California, San Francisco.
NCT02440815 is a NA study that has completed, run by University of California, San Francisco. The registered enrollment target is 108 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02440815, a NA study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- NA
- Development phase
- 108 participants
- Enrollment target
Study Summary
The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter (WM) lesion burden, and measures of cognitive function in subjects with Late Life Major Depressive Disorder (LLD). This research goal will be achieved by recruiting 110 individuals over the age of 65 with LLD. The primary outcomes will be change in CBF, change in GM atrophy, change in WM lesion, change in cognitive function, and change in depression severity from baseline to the end of 12 weeks of PST.
Primary Outcome
CBF will be measured using multimodal MRI processing (individual 2D pseudo ASL image frames). We will pursue a cortical surface-based analysis approach which allows for better spatial normalization of cortical data compared to voxel-based approaches.
Interventions
- BEHAVIORAL Problem Solving Therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 108 participants |
| Start Date | 2015-11 |
| Est. Completion | 2021-07-28 |
| Phase | NA |
What the finished NCT02440815 record still lists
NCT02440815 is an interventional study that assigns participants to a tested intervention. The registered 108 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which Problem Solving Therapy is the first listed.
NCT02440815 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02440815 about?
NCT02440815 is a clinical study titled "Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression". The specific focus of this study is to gather data regarding the effects of a psychological therapy known as Problem Solving Therapy (PST) on cerebral blood flow (CBF), cortical gray matter (GM) atrophy, subcortical white matter (WM) lesion burden, and measures of cognitive function in subjects with...
What is the current status of trial NCT02440815?
This trial is currently completed. It is a NA study. The enrollment target is 108 participants. The study started on 2015-11. Estimated completion is 2021-07-28.
What interventions are being tested in trial NCT02440815?
The interventions under investigation include: Problem Solving Therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT02440815?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02440815's enrollment target sits among peer trials
108 825th of 2000 higher than 1,171 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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