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NCT02420847 · ClinicalTrials.gov registry record · Phase 1
Ixazomib Citrate With Gemcitabine Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Urothelial Cancer That is Metastatic or Cannot Be Removed by Surgery
A Phase 1 study of Metastatic Urothelial Carcinoma and Transitional Cell Carcinoma, sponsored by M.D. Anderson Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 57
- Enrollment target
- 1
- Study location
NCT02420847: Active Phase 1 study of Metastatic Urothelial Carcinoma and Transitional Cell Carcinoma, sponsored by M.D. Anderson Cancer Center.
NCT02420847 is a Phase 1 study of Metastatic Urothelial Carcinoma and Transitional Cell Carcinoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 57 participants, below the 129-participant average among 30 other Metastatic Urothelial Carcinoma trials with a reported enrollment target (56% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02420847, a Phase 1 study of Metastatic Urothelial Carcinoma and Transitional Cell Carcinoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 57 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I/II trial studies the side effects and best dose of ixazomib citrate, gemcitabine hydrochloride, and doxorubicin hydrochloride when given together in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery. Ixazomib citrate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as gemcitabine hydrochloride and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ixazomib citrate together with gemcitabine hydrochloride and doxorubicin hydrochloride may be a better treatment for urothelial cancer.
Conditions Studied
Interventions
- DRUG Doxorubicin Hydrochloride
- DRUG Gemcitabine Hydrochloride
- DRUG Ixazomib Citrate
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2015-07-03 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 1 |
What the registry record for NCT02420847 still lists
NCT02420847 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 57 participants, a relatively small participant target, below the 129-participant average among 30 other Metastatic Urothelial Carcinoma trials with a reported enrollment target (56% lower).
The record links to 3 conditions, with Metastatic Urothelial Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Doxorubicin Hydrochloride is the first listed.
NCT02420847 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT02420847 about?
NCT02420847 is a clinical study titled "Ixazomib Citrate With Gemcitabine Hydrochloride and Doxorubicin Hydrochloride in Treating Patients With Urothelial Cancer That is Metastatic or Cannot Be Removed by Surgery". This phase I/II trial studies the side effects and best dose of ixazomib citrate, gemcitabine hydrochloride, and doxorubicin hydrochloride when given together in treating patients with urothelial cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery. Ixazomi...
What is the current status of trial NCT02420847?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 57 participants. The study started on 2015-07-03. Estimated completion is 2025-12-31.
What conditions does trial NCT02420847 study?
This clinical trial studies the following conditions: Metastatic Urothelial Carcinoma, Transitional Cell Carcinoma, Unresectable Transitional Cell Carcinoma.
What interventions are being tested in trial NCT02420847?
The interventions under investigation include: Doxorubicin Hydrochloride (DRUG), Gemcitabine Hydrochloride (DRUG), Ixazomib Citrate (DRUG).
Who is sponsoring clinical trial NCT02420847?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02420847 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02420847's enrollment target sits among peer trials
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participants (enrollment target), bucketed by value
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