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NCT02414113 · ClinicalTrials.gov registry record
Study for the Evaluation of a GVHD Negative Outcome Score (GNOS) in Matched Unrelated or Haploidentical Hematopoietic Stem Cell Transplant
A clinical trial, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- 113
- Enrollment target
NCT02414113 is a clinical trial that has completed, run by Washington University School of Medicine. The registered enrollment target is 113 participants.
The verdict
NCT02414113 has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- 113 participants
- Enrollment target
Study Summary
Before considering high-GVHD Negative Outcome Score (GNOS) donor selection for routine clinical practice, this blinded prospective study will be carried out for assessment of severe GVHD (graft-versus-host-disease) reduction associated with selecting high-GNOS donors for allogeneic hematopoietic peripheral blood stem cell transplant. The objective of this prospective study is to show: (a) that GVHD reductions and donor availabilities as observed in the retrospective studies also apply to prospective samples that are collected and processed from on-going matched unrelated transplants, and (b) that high-GNOS donor selection readily fits into today's donor selection process, such as to facilitate access to the benefits of GVHD reduction. The prospective study is designed to be blinded, and will not involve specific donor selection nor any influence on clinical management or decision making by application of the GNOS technology. To determine if some GNOS models perform better than others across different clinical centers, or across different recipient / donor attributes, 4 different specific GNOS models will be evaluated. Bootstrap computational analyses have been carried out on the retrospective data for the 4 GNOS models and will be tested and validated in this prospective study.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2015-03-25 |
| Est. Completion | 2021-01-21 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02414113
The ClinicalTrials.gov registry entry for NCT02414113 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 113 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT02414113 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02414113 about?
NCT02414113 is a clinical study titled "Study for the Evaluation of a GVHD Negative Outcome Score (GNOS) in Matched Unrelated or Haploidentical Hematopoietic Stem Cell Transplant". Before considering high-GVHD Negative Outcome Score (GNOS) donor selection for routine clinical practice, this blinded prospective study will be carried out for assessment of severe GVHD (graft-versus-host-disease) reduction associated with selecting high-GNOS donors for allogeneic hematopoietic per...
What is the current status of trial NCT02414113?
This trial is currently completed. The enrollment target is 113 participants. The study started on 2015-03-25. Estimated completion is 2021-01-21.
Who is sponsoring clinical trial NCT02414113?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
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