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NCT02405832 · ClinicalTrials.gov registry record · NA
Zinc Lozenges and Their Effect on Postoperative Sore Throat Syndrome
A NA study, sponsored by University of Vermont.
- Completed
- Registry status
- NA
- Development phase
- 87
- Enrollment target
NCT02405832 is a NA study that has completed, run by University of Vermont. The registered enrollment target is 87 participants.
The verdict
NCT02405832, a NA study, has completed, sponsored by University of Vermont.
- COMPLETED
- Registry status
- NA
- Development phase
- 87 participants
- Enrollment target
Study Summary
The objective of this study is to assess the effect of preoperative administration of oral zinc lozenges on the incidence of postoperative sore throat syndrome. When patients undergo surgery with general anesthesia, they require ventilation of their lungs with the help of a flexible tube (called an endotracheal tube) that is placed through the mouth, passing the vocal cords, and into the windpipe (trachea). This tube helps oxygenate the patient, delivers anesthetic gas to the lungs, and keeps the airways open to prevent asphyxiation. The procedure is invasive and uncomfortable, and one of the most common consequences is a sore and inflamed throat after the tube is taken out. This is termed postoperative sore throat (POST). Though the intensity and severity of sore throat varies from person to person, the reported incidence is as high as 90% of patients undergoing general anesthesia. Zinc therapy has been shown in multiple studies to reduce the severity and duration of cold symptoms, and also to up-regulate the immune system. Recent studies have shown that zinc can act as an anti-inflammatory agent and can maintain the integrity of skin and mucosal membranes (which cover the inside of the mouth and throat). The aim of this study is to evaluate the effects of giving zinc lozenges before tube placement on postoperative sore throat. After written informed consent is received in pre-op, a sealed and coded envelope with either the zinc lozenge or the placebo lozenge will be given to the patient to be administered orally, with the instruction to dissolve the lozenge by sucking on it 30 minutes prior to surgery. Upon completion of surgery and emergence from general anesthesia, the patient will be extubated and transferred to the post-anesthesia care unit (PACU). Once in the PACU, the patient will be assessed regarding the incidence and severity of POST by the study investigator using a standardized scale. The severity of POST will be graded on a 4-point scale ranging fro
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT Zinc
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 87 participants |
| Start Date | 2015-03-10 |
| Est. Completion | 2015-04-04 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02405832
The ClinicalTrials.gov registry entry for NCT02405832 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 87 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Vermont, which has 162 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02405832 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02405832 about?
NCT02405832 is a clinical study titled "Zinc Lozenges and Their Effect on Postoperative Sore Throat Syndrome". The objective of this study is to assess the effect of preoperative administration of oral zinc lozenges on the incidence of postoperative sore throat syndrome. When patients undergo surgery with general anesthesia, they require ventilation of their lungs with the help of a flexible tube (called an...
What is the current status of trial NCT02405832?
This trial is currently completed. It is a NA study. The enrollment target is 87 participants. The study started on 2015-03-10. Estimated completion is 2015-04-04.
What interventions are being tested in trial NCT02405832?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Zinc (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT02405832?
This trial is sponsored by University of Vermont, which has 162 total clinical trials registered on ClinicalTrials.gov.
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