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NCT02404194 · ClinicalTrials.gov registry record · NA
Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis
A NA study of Clinical High Risk for Psychosis, sponsored by Rush University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 139
- Enrollment target
- 1
- Study location
NCT02404194 is a NA study of Clinical High Risk for Psychosis that has completed, run by Rush University Medical Center. The registered enrollment target is 139 participants. The trial reports 1 study location across 1 state.
The verdict
NCT02404194, a NA study of Clinical High Risk for Psychosis, has completed, sponsored by Rush University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 139 participants
- Enrollment target
- 1
- Study location
Study Summary
This project is a randomized-controlled trial to test the efficacy of computer-based targeted cognitive training (TCT) versus a placebo intervention of commercial computer games in adolescent/young adults at clinical high risk (CHR) for psychosis. TCT is designed to optimize learning-induced neuroplasticity in vulnerable neurocognitive systems. A main aim is to test the hypothesis that this neuroscience-guided TCT intervention will improve neural function, and that these neural improvements will improve cognition and functional outcome. CHR participants will be randomly assigned to 40 hours of TCT or placebo computer games completed within 10 weeks. TCT consists of 20 hours of training in cognition, including processing speed, memory, attention, and cognitive control followed by 20 hours of training in social cognition including affect recognition and theory of mind. Neuroimaging, cognition, social cognition, clinical symptoms, and functional status will be assessed at baseline, after 20 hours/5 weeks of cognitive training (mid-intervention), and after 20 hours/5 weeks of social-cognitive training (post-intervention). Cognition, social cognition, symptoms, and functioning will also be assessed at a 9 month follow-up (i.e. 9 months after intervention completion). We predict that TCT will lead to improvements in neurocognitive function and functional status. The results of this study will provide important information about a benign, non-pharmacological intervention for improving cognition and functional outcome in CHR individuals.
Conditions Studied
Interventions
- BEHAVIORAL Targeted Cognitive Training
- BEHAVIORAL Computer Games
Study Locations (1)
Illinois
- Rush University Medical Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 139 participants |
| Start Date | 2015-03 |
| Est. Completion | 2021-02-15 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02404194
The ClinicalTrials.gov registry entry for NCT02404194 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 139 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Rush University Medical Center, which has 320 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Clinical High Risk for Psychosis appearing as the primary indexed condition, and to 2 interventions - of which Targeted Cognitive Training is the first listed.
NCT02404194 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.
Frequently Asked Questions
What is clinical trial NCT02404194 about?
NCT02404194 is a clinical study titled "Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis". This project is a randomized-controlled trial to test the efficacy of computer-based targeted cognitive training (TCT) versus a placebo intervention of commercial computer games in adolescent/young adults at clinical high risk (CHR) for psychosis. TCT is designed to optimize learning-induced neuropl...
What is the current status of trial NCT02404194?
This trial is currently completed. It is a NA study. The enrollment target is 139 participants. The study started on 2015-03. Estimated completion is 2021-02-15.
What conditions does trial NCT02404194 study?
This clinical trial studies the following conditions: Clinical High Risk for Psychosis.
What interventions are being tested in trial NCT02404194?
The interventions under investigation include: Targeted Cognitive Training (BEHAVIORAL), Computer Games (BEHAVIORAL).
Who is sponsoring clinical trial NCT02404194?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02404194 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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