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NCT02391480 · ClinicalTrials.gov registry record · Phase 1
A Study Evaluating the Safety and Pharmacokinetics of ABBV-075 in Subjects With Cancer
A Phase 1 study, sponsored by AbbVie.
- Completed
- Registry status
- Phase 1
- Development phase
- 128
- Enrollment target
NCT02391480: Completed Phase 1 study, sponsored by AbbVie.
NCT02391480 is a Phase 1 study that has completed, run by AbbVie. The registered enrollment target is 128 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (113% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02391480, a Phase 1 study, has completed, sponsored by AbbVie.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 128 participants
- Enrollment target
Study Summary
This is a Phase 1, first-in-human, dose escalation study in participants with advanced solid tumors to determine the pharmacokinetics, maximum tolerated dose and the recommended Phase 2 dose of ABBV-075 at different monotherapy dosing schedules. In addition the study will evaluate the safety. tolerability and the pharmacokinetics of ABBV-075 monotherapy or combination therapy in disease specific expansion cohorts.
Primary Outcome
Maximum tolerated dose is defined as the highest dose level at which less than 2 of 6 participants experience the same dose limiting toxicity. If more than 2 participants experience a different dose limiting toxicity, the maximum tolerated dose may be further evaluated or determined to be exceeded based on discussions with the investigators and medical monitors.
Interventions
- DRUG Venetoclax
- DRUG ABBV-075
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 128 participants |
| Start Date | 2015-04-14 |
| Est. Completion | 2019-07-05 |
| Phase | Phase 1 |
What the finished NCT02391480 record still lists
NCT02391480 is an interventional study that assigns participants to a tested intervention. The registered 128 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (113% higher).
The record links to 0 conditions, and to 2 interventions - of which Venetoclax is the first listed.
NCT02391480 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02391480 about?
NCT02391480 is a clinical study titled "A Study Evaluating the Safety and Pharmacokinetics of ABBV-075 in Subjects With Cancer". This is a Phase 1, first-in-human, dose escalation study in participants with advanced solid tumors to determine the pharmacokinetics, maximum tolerated dose and the recommended Phase 2 dose of ABBV-075 at different monotherapy dosing schedules. In addition the study will evaluate the safety. tolera...
What is the current status of trial NCT02391480?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 128 participants. The study started on 2015-04-14. Estimated completion is 2019-07-05.
What interventions are being tested in trial NCT02391480?
The interventions under investigation include: Venetoclax (DRUG), ABBV-075 (DRUG).
Who is sponsoring clinical trial NCT02391480?
This trial is sponsored by AbbVie, which has 526 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02391480's enrollment target sits among peer trials
128 452nd of 2000 higher than 1,542 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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