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NCT02389465 · ClinicalTrials.gov registry record · Phase 4
Stress and Inflammation in Late-Life Depression
A Phase 4 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 4
- Development phase
- 119
- Enrollment target
NCT02389465: Completed Phase 4 study, sponsored by University of Pennsylvania.
NCT02389465 is a Phase 4 study that has completed, run by University of Pennsylvania. The registered enrollment target is 119 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02389465, a Phase 4 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 119 participants
- Enrollment target
Study Summary
Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease. This study investigates the relationship between inflammation in the brain and depression. Comparing biological and psychological differences in depressed and non-depressed people allows researchers to find better ways to treat and prevent depression. All participants will have: neuropsychological tests, an EKG, a spinal tap, a blood draw, and, if depressed, given either an antidepressant coupled with an anti-inflammatory medication or an anti-depressant coupled with a placebo for six weeks. The investigators are trying to correlate brain function with depression levels and biomarkers from the blood and spinal fluid.
Primary Outcome
IL6 levels were measured in participants by blood draw 6 weeks after the first dose was given.
Interventions
- DRUG Escitalopram + Celecoxib
- DRUG Escitalopram + Placebo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 119 participants |
| Start Date | 2014-08 |
| Est. Completion | 2022-07-18 |
| Phase | Phase 4 |
What the finished NCT02389465 record still lists
NCT02389465 is an interventional study that assigns participants to a tested intervention. The registered 119 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 2 interventions - of which Escitalopram + Celecoxib is the first listed.
NCT02389465 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02389465 about?
NCT02389465 is a clinical study titled "Stress and Inflammation in Late-Life Depression". Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease. This study investigates the relationship between inflammation in the brain and depression. Comparing biological and psychological differences in d...
What is the current status of trial NCT02389465?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 119 participants. The study started on 2014-08. Estimated completion is 2022-07-18.
What interventions are being tested in trial NCT02389465?
The interventions under investigation include: Escitalopram + Celecoxib (DRUG), Escitalopram + Placebo (DRUG).
Who is sponsoring clinical trial NCT02389465?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02389465's enrollment target sits among peer trials
119 712th of 2000 higher than 1,288 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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