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NCT02359864 · ClinicalTrials.gov registry record · NA
Study of Low Dose Whole Brain Irradiation in the Treatment of Alzheimer's Disease
A NA study, sponsored by Corewell Health East.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT02359864: Clinical Trial NA study, sponsored by Corewell Health East.
NCT02359864 is a NA study that was terminated before completion, run by Corewell Health East. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02359864, a NA study, was terminated before completion, sponsored by Corewell Health East.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
This study is designed to assess the safety and toxicity/adverse events associated with the use of low dose fractionated whole brain irradiation in those patients who have been diagnosed with probable Alzheimer's disease according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria. As a secondary goal it will establish whether or not the intervention with low dose whole brain irradiation might change the recognized progression of Alzheimer's Disease. The investigators will also collect information from the florbetaben F 18 Injection (AMYVID®) positron emission tomography (PET) Scans to determine if there is any correlation between neurocognitive/quality of life scores and changes in amyloid plaque size, number and location.
Primary Outcome
To assess a change from baseline in adverse conditions, utilizing Common Terminology Toxicity Criteria (Version 5.0) assessing skin, eyes, ears, and central nervous system at 6 weeks post-treatment. Each condition/event will be given a score based on severity . The CTCAE displays Grades 1 through 5 with unique clinical descriptions of severity for each adverse event (AE): (Grade 1=1 point, Grade 2=2 points, Grade 3=3 points, Grade 4=4 points. Grade 5=5 points) and event scores added to produce a
Interventions
- RADIATION 5 daily fractions of 2 Gy
- RADIATION 10 daily fractions of 2 Gy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2021-02-03 |
| Phase | NA |
Why NCT02359864 stopped before completion
NCT02359864 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 2 interventions - of which 5 daily fractions of 2 Gy is the first listed.
NCT02359864 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02359864 about?
NCT02359864 is a clinical study titled "Study of Low Dose Whole Brain Irradiation in the Treatment of Alzheimer's Disease". This study is designed to assess the safety and toxicity/adverse events associated with the use of low dose fractionated whole brain irradiation in those patients who have been diagnosed with probable Alzheimer's disease according to the National Institute of Neurological and Communicative Disorders...
What is the current status of trial NCT02359864?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2019-10-01. Estimated completion is 2021-02-03.
What interventions are being tested in trial NCT02359864?
The interventions under investigation include: 5 daily fractions of 2 Gy (RADIATION), 10 daily fractions of 2 Gy (RADIATION).
Who is sponsoring clinical trial NCT02359864?
This trial is sponsored by Corewell Health East, which has 106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02359864's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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