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NCT02282423 · ClinicalTrials.gov registry record · NA
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
A NA study, sponsored by Mayo Clinic.
- Terminated
- Registry status
- NA
- Development phase
- 26
- Enrollment target
NCT02282423: Clinical Trial NA study, sponsored by Mayo Clinic.
NCT02282423 is a NA study that was terminated before completion, run by Mayo Clinic. The registered enrollment target is 26 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02282423, a NA study, was terminated before completion, sponsored by Mayo Clinic.
- TERMINATED
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
Study Summary
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
Primary Outcome
To determine whether expression of the transcription factor MZF1 is induced by exercise to a greater degree in control patients than in those with type 2 diabetes mellitus. MZF1 expression will be determined using quantitative rt-PCR analysis on RNA isolated from muscle biopsies taken from the patients. An repeated measures analysis of variance will be performed on the PCR data, for the three groups (lean, obese, type 2 diabetic), with the difference between the lean and diabetic groups being th
Interventions
- BEHAVIORAL Pre-study dietary and exercise instruction.
- PROCEDURE Screening examination and oral glucose tolerance test
- PROCEDURE Euglycemic clamp
- PROCEDURE VO2max.
- BEHAVIORAL Acute exercise bout
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2014-05 |
| Est. Completion | 2016-04 |
| Phase | NA |
Why NCT02282423 stopped before completion
NCT02282423 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 5 interventions - of which Pre-study dietary and exercise instruction. is the first listed.
NCT02282423 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02282423 about?
NCT02282423 is a clinical study titled "PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes". The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
What is the current status of trial NCT02282423?
This trial is currently terminated. It is a NA study. The enrollment target is 26 participants. The study started on 2014-05. Estimated completion is 2016-04.
What interventions are being tested in trial NCT02282423?
The interventions under investigation include: Pre-study dietary and exercise instruction. (BEHAVIORAL), Screening examination and oral glucose tolerance test (PROCEDURE), Euglycemic clamp (PROCEDURE), VO2max. (PROCEDURE), Acute exercise bout (BEHAVIORAL).
Who is sponsoring clinical trial NCT02282423?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02282423's enrollment target sits among peer trials
26 1710th of 2000 higher than 289 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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