Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

NCT02254278 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II trial studies the side effects and how well modestly reduced-dose intensity-modulated radiation therapy (IMRT) with or without cisplatin works in treating patients with oropharyngeal cancer that has spread to other places in the body (advanced). Radiation therapy uses high energy x rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether IMRT is more effective with or without cisplatin in treating patients with oropharyngeal cancer.

Interventions

  • DRUG Cisplatin
  • RADIATION IMRT 6 weeks
  • RADIATION IMRT 5 weeks

Study Locations (20)

California

  • Alta Bates Summit Medical Center-Herrick Campus — Berkeley
  • Mills-Peninsula Medical Center — Burlingame
  • Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park
  • City of Hope Comprehensive Cancer Center — Duarte
  • Marin General Hospital — Greenbrae
  • UC San Diego Moores Cancer Center — La Jolla
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles
  • Memorial Medical Center — Modesto
  • Kaiser Permanente Oakland-Broadway — Oakland
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange
  • Palo Alto Medical Foundation Health Care — Palo Alto
  • Stanford Cancer Institute Palo Alto — Palo Alto
  • Kaiser Permanente-Rancho Cordova Cancer Center — Rancho Cordova
  • Rohnert Park Cancer Center — Rohnert Park
  • Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville
  • The Permanente Medical Group-Roseville Radiation Oncology — Roseville
  • Sutter Medical Center Sacramento — Sacramento

Arizona

  • Banner MD Anderson Cancer Center — Gilbert
  • Banner University Medical Center - Tucson — Tucson

Alabama

  • University of Alabama at Birmingham Cancer Center — Birmingham

Trial Details

FieldValue
Enrollment Target 316 participants
Start Date 2014-10
Est. Completion 2025-09-04
Phase Phase 2

Sponsor

NRG Oncology

162 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02254278

The ClinicalTrials.gov registry entry for NCT02254278 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 316 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NRG Oncology, which has 162 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Tongue Carcinoma appearing as the primary indexed condition, and to 3 interventions — of which Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02254278 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Arizona, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02254278 about?

NCT02254278 is a clinical study titled "Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer". This randomized phase II trial studies the side effects and how well modestly reduced-dose intensity-modulated radiation therapy (IMRT) with or without cisplatin works in treating patients with oropharyngeal cancer that has spread to other places in the body (advanced). Radiation therapy uses high e...

What is the current status of trial NCT02254278?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 316 participants. The study started on 2014-10. Estimated completion is 2025-09-04.

What conditions does trial NCT02254278 study?

This clinical trial studies the following conditions: Tongue Carcinoma, Stage III Oropharyngeal Squamous Cell Carcinoma, Stage IVA Oropharyngeal Squamous Cell Carcinoma, Stage IVB Oropharyngeal Squamous Cell Carcinoma, Stage IVC Oropharyngeal Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02254278?

The interventions under investigation include: Cisplatin (DRUG), IMRT 6 weeks (RADIATION), IMRT 5 weeks (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02254278?

This trial is sponsored by NRG Oncology, which has 162 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02254278 being conducted?

This trial has 20 study locations across Alabama, Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial