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Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia
NCT02242942 · View on ClinicalTrials.gov ↗
Study Summary
This open-label, multicenter, randomized Phase III study is designed to compare the efficacy and safety of a combined regimen of obinutuzumab and venetoclax versus obinutuzumab + chlorambucil in participants with chronic lymphocytic leukemia (CLL) and coexisting medical conditions. The time on study treatment was approximately one year and the follow-up period will be up to 9 years
Conditions Studied
Interventions
- DRUG Obinutuzumab
- DRUG Venetoclax
- DRUG Chlorambucil
Study Locations (20)
Other
- Hospital Italiano — Buenos Aires
- Tiroler Landeskrankenanstalten Ges.M.B.H. — Innsbruck
- Medizinische Universität Wien — Vienna
Victoria
- Box Hill Hospital — Box Hill
- The Northern Hospital — Epping
- Monash Medical Centre — Melbourne
California
- City of Hope — Duarte
- UC San Diego Health System — La Jolla
New South Wales
- Liverpool Hospital — Liverpool BC
- Tweed Hospital — Tweed Heads
Queensland
- The Townsville Hospital — Douglas
- Princess Alexandra Hospital Woolloongabba — Woolloongabba
South Australia
- Royal Adelaide Hospital — Adelaide
- Ashford Cancer Centre Research — Ashford
Arizona
- Banner MD Anderson Cancer Center — Gilbert
Florida
- Moffitt Cancer Center — Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 445 participants |
| Start Date | 2014-12-31 |
| Est. Completion | 2025-08-27 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02242942
The ClinicalTrials.gov registry entry for NCT02242942 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 445 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Lymphocytic Leukemia, Chronic appearing as the primary indexed condition, and to 3 interventions — of which Obinutuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02242942 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, Victoria, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02242942 about?
NCT02242942 is a clinical study titled "Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia". This open-label, multicenter, randomized Phase III study is designed to compare the efficacy and safety of a combined regimen of obinutuzumab and venetoclax versus obinutuzumab + chlorambucil in participants with chronic lymphocytic leukemia (CLL) and coexisting medical conditions. The time on study...
What is the current status of trial NCT02242942?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 445 participants. The study started on 2014-12-31. Estimated completion is 2025-08-27.
What conditions does trial NCT02242942 study?
This clinical trial studies the following conditions: Lymphocytic Leukemia, Chronic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02242942?
The interventions under investigation include: Obinutuzumab (DRUG), Venetoclax (DRUG), Chlorambucil (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02242942?
This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02242942 being conducted?
This trial has 20 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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